Anti-cancer

Showing 1–16 of 41 results

Product info

Catalog Id
Size
Price
a-950-500
500 μg
90.00
a-950-1
1 mg
130.00
a-950-5
5 mg
338.00
Description

Product info

Catalog Id
Size
Price
a-101-5
5 mg
Description

Product info

Catalog Id
Size
Price
a-570-100
100 g
226.00
a-570-250
250 g
412.00
a-570-500
500 g
662.00
a-570-1000
1 kg
1,224.00
Description

Amygdalin is a glucoside derived from almonds and apricot kernels. While it was originally suggested that amygdalin is an anticancer agent, it is avoided due to its cyanogenic properties. Upon being metabolized by β-glucosidase enzymes, amygdalin produces hydrogen cyanide, which is cytotoxic on tumor cells. Amygdalin is freely soluble in aqueous solution and is used to study cytotoxic effects of cyanide on cancer cells and can be useful in identification and analysis of maltases, emulsins, and β-glucosidases.

Product Specifications
Amygdalin
D-Mandelonitrile 6-O-β-D-glucosido-β-D-glucoside

MOLECULAR BIOLOGY GRADE

Formula: C20H27NO11

MW: 457.43 g/mol

Storage/Handling: Store in a well-ventilated and dry area.

PubChem Chemical ID: 656516

Product info

Catalog Id
Size
Price
b-600-5
5 mg
Description

Product info

Catalog Id
Size
Price
b-910-10
10 mg
258.00
b-910-50
50 mg
897.00
Description

Product info

Catalog Id
Size
Price
b-930-5
5 mg
148.00
b-930-50
50 mg
543.00
Description

Brefeldin A is an antibiotic derived from Penicillium brefeldianum. It is an anti-cancer agent which disrupts protein transport and causes apoptosis of tumor cells. Brefeldin A disrupts the function of the Golgi apparatus and blocks Golgi-COPI activity. ER vesicles are prevented from fusion with the Golgi and are secretion is inhibited. Additionally, Brefeldin A is an ARF inhibitor, sphingomyelin cycle activator, and caspase-3 activator. It has been shown to induce apoptosis in leukemia cells and colon cancer cells.

Product Specifications
Brefeldin A

MOLECULAR BIOLOGY GRADE

Formula: C16H24O4

MW: 280.36 g/mol

Storage/Handling: Store at 4°C.

Brefeldin A is soluble in DMSO, acetone, or ethanol. It is insoluble in water.

PubChem CID: 5287620

Product info

Catalog Id
Size
Price
c-285-1
1 mg
Description

Cecropin A is a 37 amino acid chain that functions as an antibacterial and anti-cancer peptide. It is characterized by two alpha helices and has been researched because of the low cytotoxicity produced. Cecropin A produces synergistic effects with some chemotherapeutic agents, enhancing cytotoxic activity.

Cecropin A has been shown to cause bacterial and cancerous cell death by insertion into the cellular membrane due to amphiphilic N-terminal residues. In low lipid to peptide membrane component ratios, cecropin A will form ion channels that will disrupt metabolic gradients and lead to cell death. With high membrane peptide concentrations, cecropin A was observed to aggregate membrane peptides and break the membrane into fragments.

Product Specifications
Cecropin A
P9A Protein

Formula: C184H313N53O46

MW: ~4 kDa

Storage/Handling: Store desiccated at -20°C.

PubChem Chemical ID: 16132345

Product info

Catalog Id
Size
Price
c-625-1
1 mg
Description

Cecropin B is a 35 amino acid chain that functions as an antibacterial and anti-cancer peptide. It is characterized by two alpha helices and has been researched because of the low cytotoxicity produced. Cecropin B has been shown to produce in vivo cytotoxic effects against stomach carcinomas. It has also been used to synthesize derivatives with activity against other cancer cell lines.

Cecropin B has been shown to cause bacterial and cancerous cell death by insertion into the cellular membrane, which is due to amphiphilic N-terminal residues. In low lipid to peptide membrane component ratios, cecropin B will form ion channels that will disrupt metabolic gradients and lead to cell death. With high membrane peptide concentrations, cecropin B was observed to aggregate membrane peptides and break the membrane into fragments.

Product Specifications
Cecropin B
P9B Protein

Formula: C176H301N51O42S

MW: 3.84 kDa

Storage/Handling: Store desiccated at -20°C.

PubChem Chemical ID: 16130488

Product info

Catalog Id
Size
Price
c-545-10
10 mg
585.00
c-545-25
25 mg
836.00
Description

Cephalomannine is an alkaloid compound derived from the plant Cephalotaxus manii and is a precursor of paclitaxel. It is used for its antineoplastic capabilities, which allow it to stabilize and halt microtubule formation during mitosis. Stalling microtubule formation increases Raf-1 expression stimulating downstream apoptotic pathways.

Product Specifications
Cephalomannine

Formula: C45H53NO14

MW: 831.90 g/mol

Storage/Handling: Store desiccated at -20°C.

PubChem Chemical ID: 5281819

Product info

Catalog Id
Size
Price
c-910-500
500 mg
102.00
c-910-1
1 g
134.00
Description

Colchicine is an alkaloid isolated from Colchicum autumnale and other Colchica species. It is an antimitotic agent useful against various cancer cell lines. Colchicine disrupts microtubules and can be used to induce tetraploidy in plant cells. It is an activator of the JNK/SAPK signaling pathway and used to select for cells containing MDCK (NBL-2) resistance. Colchicine’s antimitotic properties are more effective against cancer cells due to their increased mitotic rate compared to that of healthy cells. Colchicine is useful in cell division studies.

Product Specifications
Colchicine

MOLECULAR BIOLOGY GRADE

Formula: C22H25NO6

MW: 399.44 g/mol

Storage/Handling: Store at 2-8 °C.
This product is light sensitive.

PubChem Chemical ID: 6167

Air shipments may require special packaging and a small additional box charge.

Product info

Catalog Id
Size
Price
c-735-10
10 mg
186.00
c-735-25
25 mg
418.00
Description

Cryptotanshinone is a quinoid diterpene extracted from Salvia miltiorrhiza Bunge and has been used as an antibacterial, anti-inflammatory and anti-cancer compound. As an antibacterial agent, cryptotanshinone exhibits a broad range of activity against gram positive bacteria. In vivo studies of bactericidal mechanisms have shown cryptotanshinone to form superoxides which damage bacterial proteins, lipids and DNA.

Cryptotanshinone has also been used as an anti-inflammatory by inhibiting both nuclear factor-κB (NF-κB) activation and phosphorylation of mitogen-activated protein kinases (MAPK). The anti-inflammatory actions occur in downstream pathways, inhibiting p38 MAPK, c-Jun N-terminal kinases (JNKs) and lipopolysaccharide induced inflammation. Inhibition of these pathways and molecules will decrease pro-inflammatory pathway responses as well as cytokine synthesis.

As an anti-cancer agent, cryptotanshinone was used to inhibit cancer cell proliferation through the decreased expression of cyclin D1 or increase in cyclin A1 and cyclin B1 expression. It was also used to impede cancer motility by inhibiting complement component 5a protein (C5a), an analphylatoxin. Cryptotanshinone has also been used to reduce cell motility by inhibiting basic fibroblast growth factor (bFGF), a promoter of angiogenesis. Apoptotic effects were also observed by cryptotanshinone when it was used to inhibit signal transducer and activator of transcription-3 expression, which upregulates cell survival pathways.

Product Specifications
Cryptotanshinone
Tanshinone C

Formula: C19H20O3

MW: 296.36 g/mol

Storage/Handling: Store desiccated at 4°C.
Soluble in DMSO, methanol and ethanol.

PubChem Chemical ID: 160254

Product info

Catalog Id
Size
Price
c-940-100
100 mg
92.00
c-940-500
500 mg
342.00
Description

The cyclosporins are a group of macrolide immunosuppressants isolated from fungi. They are researched for their use in prevention of post-transplant graft rejection. Their mechanism of action involves suppression of cytotoxic T-cell maturation and activity by binding lymphocyte protein cyclophilin. Cyclophilin and cyclosporin form a complex targeting calcineurin, which is responsible for activating T-lymphocytes. Additionally, the cyclosporins are researched for their ability to prevent damage to normal functioning cells in autoimmune disorders.

Cyclosporin A is over 99% pure and soluble in DMSO and ethyl alcohol.

Product Specifications
Cyclosporin A

Formula: C62H111N11O12

MW: 1,202.61 g/mol

Storage/Handling: Store at 2-8°C.  Soluble in DMSO and EtOH.

PubChem Chemical ID: 5284373

Product info

Catalog Id
Size
Price
c-942-5
5 mg
Description

The cyclosporins are a group of macrolide immunosuppressants isolated from fungi. They are researched for their use in prevention of post-transplant graft rejection. Their mechanism of action involves suppression of cytotoxic T-cell maturation and activity by binding lymphocyte protein cyclophilin. Cyclophilin and cyclosporin form a complex targeting calcineurin, which is responsible for activating T-lymphocytes. Additionally, the cyclosporins are researched for their ability to prevent damage to normal functioning cells in autoimmune disorders.

Cyclosporin B is soluble in DMSO and ethyl alcohol.

Product Specifications
Cyclosporin B

Formula: C61H109N11O12

MW: 1,188.58 g/mol

Storage/Handling: Store at 2-8°C.  Soluble in DMSO and EtOH.

PubChem Chemical ID: 6450331

Product info

Catalog Id
Size
Price
c-943-5
5 mg
258.00
c-943-10
392.00
c-943-25
616.00
c-943-50
926.00
Description

The cyclosporins are a group of macrolide immunosuppressants isolated from fungi. They are researched for their use in prevention of post-transplant graft rejection. Their mechanism of action involves suppression of cytotoxic T-cell maturation and activity by binding lymphocyte protein cyclophilin. Cyclophilin and cyclosporin form a complex targeting calcineurin, which is responsible for activating T-lymphocytes. Additionally, the cyclosporins are researched for their ability to prevent damage to normal functioning cells in autoimmune disorders.

Cyclosporin C is soluble in DMSO and ethyl alcohol.

Product Specifications
Cyclosporin C

Formula: C62H111N11O13

MW: 1,218.61 g/mol

Storage/Handling: Store at -20°C.
Soluble in DMSO and EtOH

PubChem Chemical ID: 53395167

Product info

Catalog Id
Size
Price
c-944-5
5 mg
Description

The cyclosporins are a group of macrolide immunosuppressants isolated from fungi. They are researched for their use in prevention of post-transplant graft rejection. Their mechanism of action involves suppression of cytotoxic T-cell maturation and activity by binding lymphocyte protein cyclophilin. Cyclophilin and cyclosporin form a complex targeting calcineurin, which is responsible for activating T-lymphocytes. Additionally, the cyclosporins are researched for their ability to prevent damage to normal functioning cells in autoimmune disorders.

Cyclosporin D is soluble in DMSO and ethyl alcohol.

Product Specifications
Cyclosporin D

Formula: C63H113N11O12

MW: 1,216.64 g/mol

Storage/Handling: Store at 4°C.

PubChem CID: 6436250

Product info

Catalog Id
Size
Price
c-947-1
1 mg
207.00
c-947-5
5 mg
807.00
Description