Anti-fungal

Showing 1–16 of 20 results

Product info

Catalog Id
Size
Price
f-500-1
1 g
219.00
f-500-5
5 g
492.00
Description

5-Fluorocytosine is a fluorinated cytosine analog and antifungal agent. 5-fluorocytosine becomes 5-fluorouracil and is then incorporated into RNA, causing miscoding and inhibition of DNA synthesis. It is effective against Candida and Cryptococcus species and can be used as a negative selection agent in transgenic plants.


5-Fluorocytosine is often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

Product Specifications
5-Fluorocytosine

MOLECULAR BIOLOGY GRADE

Formula: C4H4FN3O

MW: 129.09 g/mol

Storage/Handling: Store at 2-8°C.  Protect from light.

PubChem Chemical ID: 3366

Product info

Catalog Id
Size
Price
a-561-250
250 mg
142.00
a-561-500
500 mg
273.00
a-561-1
1 g
507.00
Description

Solubilized amphotericin B is a mixture of 45% amphotericin B, 35% sodium deoxycholate, and 10% phosphate buffer.

Amphotericin B is a polyene antifungal isolated from Streptomyces species. While it has been suggested that Amphotericin B interacts with ergosterol of the fungal cell membrane leading to an altered cell membrane permeability and death, more recent studies show that the mechanism behind amphotericin B’s fungicidal activity is more complex. It is most effective against fungi and yeast and is often used against opportunistic fungal infections and leishmaniasis. Additionally, amphotericin B can be used to prevent growth of F. oxysporum in chickpea and P. triticina in wheat.

Amphotericin B is often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

Product Specifications
Amphotericin B, Solubilized

MOLECULAR BIOLOGY GRADE

Formula: C47H73NO17

MW: 924.08 g/mol

Storage/Handling: Store at 4°C. This product is light sensitive.

PubChem Chemical ID: 5280965

Product info

Catalog Id
Size
Price
a-560-250
250 mg
74.00
a-560-500
500 mg
135.00
Description

Amphotericin B is a polyene antifungal isolated from Streptomyces species. While it has been suggested that Amphotericin B interacts with ergosterol of the fungal cell membrane leading to an altered cell membrane permeability and death, more recent studies show that the mechanism behind amphotericin B’s fungicidal activity is more complex. It is most effective against fungi and yeast and is often used against opportunistic fungal infections and leishmaniasis. Additionally, amphotericin B can be used to prevent growth of F. oxysporum in chickpea and P. triticina in wheat.

Amphotericin B is often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

Product Specifications
Amphotericin B, USP Grade

Formula: C47H73NO17

MW: 924.08 g/mol

This product is soluble in DMSO or DMF

PubChem CID: 5280965

Product info

Catalog Id
Size
Price
a-580-100
100 mg
292.00
a-580-25
88.00
Description

Anisomycin is an antifungal produced by Streptomyces griseolus. It functions by inhibiting protein synthesis in certain eukaryotic cells. Anisomycin inhibits peptidyl transferase activity in the 60s subunit of the 80s ribosome.

Anisomycin has been shown to promote apoptosis in promyelocytic leukemia cells, Jurkat cells, ventricular monocytes, and colon adenocarcinoma cells. Additionally, anisomycin is a JNK agonist and activates MAP kinases. It is a useful antiprotozoal agent.

Product Specifications
Anisomycin

MOLECULAR BIOLOGY GRADE

Formula: C14H19NO4

MW: 265.30 g/mol

Storage/Handling: Store at 4°C.

PubChem Chemical ID: 253602

Product info

Catalog Id
Size
Price
c-520-10
10 mg
Description

Caspofungin acetate is an echinocandin antifungal targeting the fungal cell membrane and inhibiting β(1,3)-D-Glucan synthase, a component necessary for cell wall synthesis. Caspofungin acetate is useful against Aspergillus and Candida species.

Caspofungin acetate is often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

Product Specifications
Caspofungin acetate
Caspofungin diacetate
Cancidas

MOLECULAR BIOLOGY GRADE

Formula: C52H88N10O15 ∙ 2C2H4O2

MW: 1,213.42 g/mol

Storage/Handling: Store at -20°C.

PubChem Chemical ID: 66577041

Product info

Catalog Id
Size
Price
c-241-1
1 mg
Description

Cecropin P1, porcine is a 31 amino acid antibacterial protein that can be isolated from pigs. Cecropin P1 is used as an antibacterial, antifungal and anti-cancer compound. The wide ranging effects of cecropin P1 are properties of its amphipathic N-terminal, lipophilic C-terminal and alpha helical structure. With these structural characteristics, cecropin P1 can bind to the membranes of pathogens and cancerous cells. Cecropin P1 then is inserted into the membrane of the respective cell and disrupts lipid bilayer cohesion, causing rapid membrane degradation and cell lysis.

Product Specifications
Cecropin P1, porcine
Cecropin P1
Porcine cecropin

Formula: C147H253N45O43

MW: 3.34 kDa

Storage/Handling: Store desiccated at -20°C.

PubChem Chemical ID: 16130477

Product info

Catalog Id
Size
Price
c-900-5
5 g
114.00
c-900-25
25 g
422.00
c-900-100
100 g
1,080.00
Description

Clotrimazole is an antifungal that targets the cell membrane of a variety of fungi including Candida and Aspergillus. It inhibits the synthesis of ergosterol causing an increase in cell membrane permeability. Additionally, clotrimazole is an activator of MB67 and inhibitor of CYP3A4 and CYP51A1.

Clotrimazole is often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

Product Specifications
Clotrimazole

MOLECULAR BIOLOGY GRADE

Formula: C22H17ClN2

MW: 344.84 g/mol

Storage/Handling: Store at 2-8°C.  Protect from light.  Clotrimazole is soluble in acetone, alcohol, chloroform, DMF, and ethyl acetate.

PubChem Chemical ID: 2812

Product info

Catalog Id
Size
Price
c-930-1
1 g
34.00
c-930-5
5 g
116.00
c-930-10
10 g
210.00
c-930-25
25 g
428.00
Description

Cycloheximide is a protein synthesis inhibitor in eukaryotic cells. It prevents ribosomal mRNA translocation during protein translation. Cycloheximide has a variety of applications. It can be used to study cellular processes and to determine the half-life of a protein using western blotting techniques of protein cell lysate. It has been used to select for CHX-resistant strains of yeast and fungi. It also displays neuroprotective properties. Additionally, Cycloheximide has been used to inhibit yeast growth at concentrations of 200μM. It has been used to promote production of ethylene in leaves and fruit.

Cycloheximide is reserved for in vitro applications due to its high toxicity.

Product Specifications
Cycloheximide

MOLECULAR BIOLOGY GRADE

Formula: C15H23NO4

MW: 281.35 g/mol

Storage/Handling: Store at room temperature. Soluble in DMSO.

PubChem Chemical ID: 6167

Air shipments may require special packaging and a small additional box charge and a dangerous goods fee.

Product info

Catalog Id
Size
Price
e-200-5
5 g
88.00
e-200-25
25 g
318.00
e-200-100
100 g
836.00
Description

Econazole Nitrate is a broad-spectrum antimycotic imidazole antifungal targeting the cell membrane of fungi. It increases cell permeability via ergosterol synthesis inhibition. It is useful against fungi that cause Tinea especially Trichophyton and Microsporum species. It can be used to study platelet serotonin uptake and the synthesis of prostanoids.

Econazole Nitrate is often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

Product Specifications
Econazole Nitrate Salt

MOLECULAR BIOLOGY GRADE

Formula: C18H15Cl3N2O ∙ HNO3

MW: 444.70 g/mol

Storage/Handling: Store at 2-8 °C. This product is light sensitive.
Econazole Nitrate is soluble in DMSO.

PubChem Chemical ID: 68589

Product info

Catalog Id
Size
Price
f-450-100
100 mg
Description

Fluconazole is a fungistatic triazole antifungal targeting ergosterol synthesis leading to increased permeability of the fungal cell membrane. It is effective against Candida species, Cryptococcus species, neoformans, and dermatophytes. Fluconazole has been shown to down-regulate the metallothionein gene and inhibit CYP2C19, CYP2C9, and CYP3A4.

Fluconazole is often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

Product Specifications
Fluconazole

MOLECULAR BIOLOGY GRADE

Formula: C13H12F2N6O

MW: 306.27 g/mol

Storage/Handling: Store at 4°C.
This product is soluble in DMSO (5 mg/ml).

PubChem Chemical ID: 3365

Product info

Catalog Id
Size
Price
g-650-5
5 g
70.00
g-650-25
25 g
255.00
g-650-50
50 g
483.00
Description

Griseofulvin is a fungistatic antifungal that targets microtubules. Isolated from Penicillium griseofulvum, Griseofulvin binds tubulin and interferes with mitosis and nucleic acid synthesis. It is effective against fungi causing tinea such as Microsporum, Epidermophyton, and Trichophyton. It has also been shown to promote apoptosis in in vitro studies of human tumor cell lines.

Griseofulvin is often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

Product Specifications
Griseofulvin

MOLECULAR BIOLOGY GRADE

Formula: C 17H17ClO6

MW: 352.77 g/mol

Storage/Handling: Store at 2-8 °C.
This product is soluble in water (8.6 µg/ml).

PubChem Chemical ID: 441140

Product info

Catalog Id
Size
Price
i-660-25
25 g
Description

Irgasan (triclosan) is a broad-spectrum antifungal and antibiotic. It is often used as a supplement to cell culture media in Pseudomonas and Yersinia isolation agars to prevent bacterial contamination. It is slightly soluble in water and freely soluble in ethanol and methanol.

Irgasan binds the enoyl-acyl carrier protein reductase and forms a complex. Consequently, NAD (nicotinamide adenine dinucleotide) binds and prevents the enoyl-ACP complex from participating in the fatty acid synthesis cycle, suppressing bacterial cell growth.

Product Specifications
Irgasan
Triclosan

MOLECULAR BIOLOGY GRADE

Formula: C12H7Cl3O2

MW: 289.54 g/mol

Storage/Handling: Store at 4°C. Soluble in ethanol or methanol.

PubChem Chemical ID: 5564

Product info

Catalog Id
Size
Price
i-670-100
100 mg
219.00
i-670-500
500 mg
746.00
Description

Itraconazole is a triazole antifungal agent used to increase fungal cell membrane permeability by inhibiting ergosterol synthesis, ultimately leading to fungal cell death. Itraconazole is effective against Blastomyces, Histoplasma, and Aspergillus species. It is used to study Candida infections in mice and to study proliferative changes in diabetic rats. Additionally, itraconazole is a hedgehog signaling inhibitor and CYP3A4 inhibitor.

Itraconazole is often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

Product Specifications
Itraconazole

Oriconazole

MOLECULAR BIOLOGY GRADE

Formula: C 35H38Cl2N8O4

MW: 705.63 g/mol

Storage/Handling: Store at 4°C.

Product is soluble in chloroform.

PubChem Chemical ID: 55283

Product info

Catalog Id
Size
Price
k-200-1
1 g
100.00
k-200-10
10 g
438.00
k-200-50
50 g
1,492.00
Description

Kasugamycin HCl is an aminoglycoside antibiotic used to combat yeast and pathogenic fungi such as M. grisea. It has been isolated from Streptomyces kasugaensis. Kasugamycin has been used to prevent and treat M. grisea mycelia formation in rice and against parasitic infections of plants such as leaf spot or apple scab. It is the antibiotic of choice in many infections due to its low phytotoxicity. Additionally, kasugamycin has been used to study ribosome structure and kasugamycin resistance.

Aminoglycoside antibiotics are composed of amino groups attached to glycosides. They bind the 30s ribosomal subunit, causing misreading of the mRNA sequence and inhibition of translocation. Consequently, protein synthesis is inhibited.

Product Specifications
Kasugamycin HCl

MOLECULAR BIOLOGY GRADE

Formula: C14H25N3O9 ∙ HCl

MW: 415.82 g/mol

Storage/Handling: Store at 2-8 °C.
Solubility of the product increases with pH.

PubChem Chemical ID: 88045

Product info

Catalog Id
Size
Price
k-300-50
50 mg
225.00
k-300-100
100 mg
300.00
k-300-500
500 mg
734.00
k-300-1
1 g
954.00
Description

Product info

Catalog Id
Size
Price
m-860-5
5 g
Description

Miconazole Nitrate is an imidazole antifungal targeting fungi responsible for causing tinea, especially Trichophyton species. It is an ergosterol synthesis inhibitor, which ultimately increases cell membrane permeability and causes fungal cell death. Miconazole nitrate inhibits platelet cyclooxygenase and induces reactive oxygen species in fungal biofilms. Additionally, it has been used to study automated luminescence-based cytochrome P450 profiling.

Miconazole Nitrate is often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

Product Specifications
Miconazole Nitrate

MOLECULAR BIOLOGY GRADE

Formula: C18H14Cl4N2O ∙ HNO3

MW: 479.14 g/mol

Storage/Handling: Store at 2-8°C.

PubChem Chemical ID: 68553