Antibiotic Solutions

Showing all 9 results

Product info

Catalog Id
Size
Price
a-301-sl10
10 mL
54.00
a-301-sl25
25 mL
92.00
a-301-sl50
50 mL
129.00
a-301-sl100
100 mL
164.00
Description

Ampicillin sodium is a member of the extended-spectrum β-lactam family and similar in structure to penicillin. It is used in the selection of antibiotic cell hybrids and has a high rate of action against many gram-negative bacterial strains. Ampicillin sodium targets non-ESBL (Extended Spectrum β-lactamase) bacteria including Staphylococcus and Streptococcus species and medically important enteric pathogens such as Shigella and Salmonella. It has been found to be effective against certain β-lactam sensitive VRE or vancomycin resistant Enterococcus species. Resistance to ampicillin is routinely utilized as a selectable marker to confirm successful cell transformation. Ampicillin Sodium is freely soluble in water.

β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Resistance to β-lactam antibiotics occurs in the presence of cells containing plasmid encoded extended spectrum β-lactamases or ESBLs.

GoldBio’s antibiotic solutions are provided ready to use.

Product Specifications
Sodium Ampicillin in H2O
(100 mg/mL Premade Solution, 0.2 µm Sterile Filtered)

MOLECULAR BIOLOGY GRADE

Formula: NaC16H18N3O4S

MW: 371.39 g/mol

Storage/Handling: Store at -20°C

PubChem Chemical ID: 23663979

Product info

Catalog Id
Size
Price
c-103-sl10
10 mL
74.00
c-103-sl25
25 mL
108.00
c-103-sl50
50 mL
146.00
c-103-sl100
100 mL
182.00
Description

Carbenicillin is a member of the penicillin β-lactam antibiotics. However, unlike most β-lactams, carbenicillin disodium is limited to primarily gram-negative bacteria including Pseudomonas aeruginosa and common enteric species. It can be used in selection protocols and is often preferred over ampicillin due to its increased stability. This allows for less contamination of unwanted bacterial colonies. In addition, carbenicillin has been used to regulate bacterial growth in plants, yielding low regeneration frequencies. It can be used in genetic transformation applications to select for AmpR transformed cells.

Penicillins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a five-membered thiazolidine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Resistance to β-lactam antibiotics occurs in the presence of cells containing plasmid encoded extended spectrum β-lactamases or ESBLs.

GoldBio’s antibiotic solutions are provided ready to use.

Product Specifications:
Carbenicillin Disodium in H2O
(100 mg/mL Pre-Made Solution, 0.2 µm Sterile Filtered)

USP GRADE

Formula: Na2C17H16N2O6S

MW: 422.36 g/mol

Storage/Handling: Store at -20°C.

PubChem Chemical ID: 20933

Product info

Catalog Id
Size
Price
c-104-sl10
10 mL
74.00
c-104-sl50
50 mL
182.00
c-104-sl100
100 mL
309.00
Description

Cefotaxime is a third generation, broad-spectrum cephalosporin antibiotic effective against various gram-negative and gram-positive bacteria. However, unlike many other cephalosporins, cefotaxime is not effective against Pseudomonas aeruginosa bacteria. Cefotaxime is often used in Agrobacterium tumefaciens-mediated transformations to regulate bacterial growth. It has been shown to exhibit a synergistic effect with Vancomycin in certain conditions.

Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.

GoldBio’s antibiotic solutions are provided ready to use.


Product Specifications:
Cefotaxime Sodium in H2O
(100 mg/mL Premade Solution, 0.2 µm Sterile Filtered)

MOLECULAR BIOLOGY GRADE

Formula: NaC16H16N5O7S2

MW: 477.45 g/mol

Storage/Handling: Store at -20°C.

PubChem Chemical ID: 10695961

Product info

Catalog Id
Size
Price
c-104-sx100
100 mL
Description

Cefotaxime is a third generation, broad-spectrum cephalosporin antibiotic effective against various gram-negative and gram-positive bacteria. However, unlike many other cephalosporins, cefotaxime is not effective against Pseudomonas aeruginosa bacteria. Cefotaxime is often used in Agrobacterium tumefaciens-mediated transformations to regulate bacterial growth. It has been shown to exhibit a synergistic effect with Vancomycin in certain conditions.

Cephalosporins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a six-membered dihydrothiazine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Cephalosporins are less susceptible to β-lactamases than the penicillin β-lactam antibiotics.

Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

GoldBio’s antibiotic solutions are provided ready to use.


Product Specifications:
Cefotaxime Sodium in H 2O
250 mg/mL Premade Solution, 0.2 µm Sterile Filtered

MOLECULAR BIOLOGY GRADE

Formula: NaC 16H16N5O7S2

MW: 477.45 g/mol

Storage/Handling: Store at -20°C.

PubChem Chemical ID: 10695961

Product info

Catalog Id
Size
Price
g-400-sl10
10 mL
74.00
g-400-sl25
25 mL
108.00
g-400-sl50
50 mL
146.00
g-400-sl100
100 mL
182.00
Description

Gentamicin is a broad-spectrum aminoglycoside antibiotic effective against gram-negative and gram-positive species. In addition, gentamicin exhibits antimicrobial properties against species resistant to tetracycline, colistin, kanamycin, and chloramphenicol.

Aminoglycoside antibiotics are composed of amino groups attached to glycosides. They bind the 30s ribosomal subunit, causing misreading of the mRNA sequence and inhibition of translocation. Consequently, protein synthesis is inhibited.

GoldBio’s antibiotic solutions are provided ready to use.

TESTED AGAINST BOTH SENSITIVE AND RESISTANT CELLS AT GOLD BIOTECHNOLOGY LABS.


Product Specifications
Gentamicin Sulfate in H2O
(50 mg/mL Premade Solution, 0.2 µm Sterile Filtered)

Formula: C21H43N5O7 · H2SO4

MW: 575.67 g/mol

Storage/Handling: Store at -20°C.

PubChem Chemical ID (for Gentamicin; without sulfate salt): 3467


Product info

Catalog Id
Size
Price
k-120-sl25
25 mL
74.00
k-120-sl50
50 mL
108.00
k-120-sl100
100 mL
146.00
Description

Kanamycin is an aminoglycoside antibiotic isolated from Streptomyces kanamyceticus. It is effective against gram-positive and gram-negative bacteria as well as Mycoplasma species. Kanamycin is commonly used to select for bacteria that have been transformed with a kanamycin-resistant gene and plant tissues that have the NPT II (APH3) gene incorporated in them. Kanamycin is very soluble in aqueous solution and is typically used in concentrations of 50-100 µg/ml.

Aminoglycoside antibiotics are composed of amino groups attached to glycosides. They bind the 30s ribosomal subunit, causing misreading of the mRNA sequence and inhibition of translocation. Consequently, protein synthesis is inhibited.

GoldBio’s antibiotic solutions are provided ready to use.

Product Specifications:
Kanamycin Monosulfate in H2O
(50 mg/mL Premade Solution, 0.2 µm Sterile Filtered)

MOLECULAR BIOLOGY GRADE

Formula: C18H36N4O11 · H2SO4

MW: 582.58 g/mol

Storage/Handling: Store at -20°C

Activity: ~800 µg/mg

PubChem Chemical ID: 32943

Product info

Catalog Id
Size
Price
s-140-sl10
10 mL
74.00
s-140-sl25
25 mL
108.00
s-140-sl50
50 mL
146.00
s-140-sl100
100 mL
182.00
Description

Spectinomycin is an aminocyclitol antibiotic isolated from Streptomyces spectabilis. It is effective against gram-positive and gram-negative bacteria, but most commonly used against Gonococcus species. It has also been used to monitor cell fate during leaf development and as a selection marker in plants to display successful transformation of the Spcr gene.

Spectinomycin functions by binding the 30s ribosomal subunit, inhibiting tRNA translation and protein synthesis. Resistance to this antibiotic is conferred through the aadA gene and mutated rpsE gene.

GoldBio’s antibiotic solutions are provided ready to use.


Product Specifications
Spectinomycin Dihydrochloride Pentahydrate in H2O
(100 mg/mL Premade Solution, 0.2 µm Sterile Filtered)

Formula: C14H24N2O7 · 2HCl · 5H2O

MW: 495.35 g/mol

Storage/Handling: Store at -20°C.

PubChem Chemical ID: 30971

Product info

Catalog Id
Size
Price
s-150-sl10
10 mL
54.00
s-150-sl25
25 mL
92.00
s-150-sl50
50 mL
129.00
s-150-sl100
100 mL
182.00
Description

Streptomycin is an aminoglycoside antibiotic primarily effective against gram-negative bacteria and Mycobacterium species. It is commonly used in cell culture media to prevent bacterial contamination. It has also been used to precipitate nucleic acids during protein purification techniques and to study mechanisms of Streptomycin resistance.

Aminoglycoside antibiotics are composed of amino groups attached to glycosides. They bind the 30s ribosomal subunit, causing misreading of the mRNA sequence and inhibition of translocation. Consequently, protein synthesis is inhibited. Resistance to this antibiotic is conferred through mutations in the rpsL gene.

GoldBio’s antibiotic solutions are provided ready to use.

TESTED AGAINST BOTH SENSITIVE AND RESISTANT CELLS AT GOLD BIOTECHNOLOGY LABS.


Product Specifications
Streptomycin Sulfate in H2O
(100 mg/mL Premade Solution, 0.2 µm Sterile Filtered)

TESTED AGAINST BOTH SENSITIVE AND RESISTANT CELLS

Formula: (C 21H39N7O12)2 · 3H2SO4

MW: 1457.38 g/mol

Storage/Handling: Store at -20°C.

PubChem Chemical ID: 19648

Product info

Catalog Id
Size
Price
t-104-sl10
10 mL
92.00
t-104-sl50
50 mL
182.00
t-104-sl100
100 mL
255.00
Description

Timentin™ is a 15:1 mixture of ticarcillin and clavulanate. Ticarcillin is a penicillin ß-lactam antibiotic, which is susceptible to ß-lactamase degradation. When combined with clavulanate, a ß-lactamase inhibitor, its efficacy is greatly increased. Timentin™ exhibits high activity against gram-negative bacteria and resistant Agrobacterium species.

Penicillins are a type of β-lactam antibiotic consisting of a four-membered β-lactam ring bound to a five-membered thiazolidine ring. This two-ring system causes distortion of the β-lactam amide bond, resulting in decreased resonance stabilization and increased reactivity. β-lactams inhibit the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins or PBPs. Consequently, the bacterial cell wall becomes weak and cytolysis occurs. Resistance to β-lactam antibiotics occurs in the presence of cells containing plasmid encoded extended spectrum β-lactamases or ESBLs.

GoldBio’s antibiotic solutions are provided ready to use.

TESTED AGAINST BOTH SENSITIVE AND RESISTANT CELLS AT GOLD BIOTECHNOLOGY LAB.

Product Specifications
Ticarcillin Disodium/Potassium Clavulanate in H2O
(100 mg/mL Premade Solution, 0.2 µm Sterile Filtered)

USP GRADE

Formula: C15H14N2Na2O6S2 / C8H8KNO5

MW: 665.64 g/mol (combined)

Storage/Handling: Store at -20°C.

PubChem Chemical ID (Ticarcillin): 470375
PubChem Chemical ID (Clavulanate): 23665591