Polypeptides

Showing all 5 results

Product info

Catalog Id
Size
Price
b-070-1
1 g
38.00
b-070-5
5 g
62.00
b-070-10
10 g
84.00
b-070-25
25 g
138.00
b-070-50
50 g
216.00
b-070-100
100 g
380.00
Description

Bacitracin is a cyclic polypeptide antibiotic isolated from Bacillus subtilis. It is made up of a variety of antimicrobial peptide fractions including A, A1, B, B1, B2, C, D, E, F, G, and X. This standard grade product is a mixture of these fractions, with bacitracin A exhibiting the most potent antimicrobial activity. Bacitracins B1 and B2 exhibit about 90% of the antimicrobial activity of bacitracin A when together. Other forms of bacitracin have not been studied extensively, but may have negligible antimicrobial properties. Bacitracin is freely soluble in aqueous solution.

Bacitracin targets the cell wall of gram-positive organisms such as Streptococcus pyogenes and Staphylococcus aureus. Bacitracin also functions as a useful tool to distinguish between group A and group B β-hemolytic Streptococcus species, which are susceptible and resistant, respectively.

Bacitracin functions through inhibiting phosphorylation of bactoprenol, a step essential to synthesize peptidoglycan. Consequently, cell lysis occurs. Bacitracin resistance is conferred through a BcrABC transporter that pumps bacitracin out of cells or through BacA which allows phosphorylation of bactoprenol via an alternative biosynthesis pathway.

Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

Product Specifications
Bacitracin, USP Grade

Formula: C66H103N17O16S

MW: 1,422.69 g/mol

Storage/Handling: Store at 2-8 °C.

PubChem Chemical ID: 24891503

Product info

Catalog Id
Size
Price
c-920-1
1 g
172.00
c-920-5
5 g
675.00
c-920-10
10 g
1,299.00
Description

Colistin is a polymyxin antibiotic effective against gram-negative bacteria. It has been used to permeabilize bacterial cell membranes and to study mannose-resistant haemagglutination. It has also been implicated in researching effective treatment for P. aeruginosa infections.

Colistin functions by targeting cell membranes and altering their permeability. Colistin sodium methanesulfonate (CMS) is considered an inactive prodrug, which means it is inactive until converted into colistin by cellular enzymes. GoldBio also offers Colistin sulfate (colistin), the end product of CMS, which does not require molecular conversion for antimicrobial properties.

Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

Product Specifications
Colistin Sodium Methanesulfonate

MOLECULAR BIOLOGY GRADE

Formula: C58H115N16Na5O28S5

MW: 1,759.90 g/mol

Storage/Handling: Store at 4°C.

PubChem Chemical ID: 16211791

Air shipments may require special packaging and a small additional box charge.

Product info

Catalog Id
Size
Price
c-921-1
1 g
28.00
c-921-5
5 g
68.00
c-921-25
25 g
208.00
c-921-100g
100 g
508.00
Description

Colistin is a cyclic polypeptide antibiotic of the polymyxin family. It targets the cell membrane of bacteria, which ultimately leads to an altered cell permeability and cell death. It primarily targets gram-negative bacteria. Colistin has been used to study mannose-resistant haemagglutination, antibiotic resistance, and nephrotoxicity.

Colistin sulfate (colistin) is the end product of Colistin Sodium Methanesulfonate (CMS) and does not require molecular conversion for antimicrobial properties.

Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

Product Specifications
Colistin Sulfate, USP Grade
Polymyxin E

Formula: C52H98N16O13 ∙ 2.5 H2SO4

MW: 2,801.26 g/mol

Storage/Handling: Store at 2-8°C.

PubChem Chem ID: 46224602

Air shipments may require special packaging and a small additional box charge.

Product info

Catalog Id
Size
Price
g-640-100
100 mg
64.00
g-640-500
500 mg
136.00
g-640-1
1 g
170.00
g-640-5
5 g
624.00
Description

Gramicidin is an antibiotic mixture of six antimicrobial polypeptides isolated from Bacillus aneurinolyticus. It targets the cell membrane of gram-positive bacteria and alters the cell membrane permeability. This leads to cell death. Gramicidin is not soluble in aqueous solution.

Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

Product Specifications
Gramicidin

MOLECULAR BIOLOGY GRADE

Formula: C99H140N20O17

MW: 1,882.29 g/mol

Storage/Handling: Store at 2-8°C.  Soluble in Methanol or Ethanol.

PubChem Chemical ID: 16130140

Product info

Catalog Id
Size
Price
p-740-10
10 MU
162.00
p-740-100
100 MU
627.00
Description

Polymyxin B sulfate is a polypeptide antibiotic mixture of B1, B2, and B3 polymyxins. Each of these fractions vary by a fatty acid group and exhibit marginal MIC differences when compared. Polymyxin B is most effective against gram-negative bacteria. It has been shown to work against Pseudomonas aeruginosa, Pseudomonas viridiflava, and Erwinia carotovora. Polymyxin B is freely soluble in aqueous solution.

Polymyxin B alters membrane permeability of gram-negative bacteria, ultimately leading to cell lysis. It works by interacting with lipopolysaccharide (LPS) and does not need to enter the cell wall.

Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.

Product Specifications
Polymyxin B Sulfate

solubility in H2O: soluble at 50 mg/ml

MOLECULAR BIOLOGY GRADE

Formula: C55H96N16O13 ∙ 2H2SO4

MW: 1,385.61 g/mol

Storage/Handling: Store at 2-8 °C.