Biochemical Reagents

  (-)-Arctigenin is a dibenzylbutyrolactone ligand found in the root of Arctium lappa L. It is an inhibitor of topoisomerase II, viral integrase including HIV-1 integrase, PAC-1, TNF-alpha, and nitric oxide secretion. Additionally, (-)-arctigenin displays anti-oxidative, anti-inflammatory, and anti-cancer properties. (-)-Arctigenin has been used in research on cosmetics and pharmaceutical products. Product Specifications: (-)-Arctigenin Formula: C₂₁H₂₄O₆ MW: 372.41 g/mol Storage/Handling: Store at -20°C.

(+)-Bicuculline, a light-sensitive competitive GABAA and GABAA-gated chloride channel antagonist, functions in the biochemical field as a drug, CNS stimulator, convulsant and neurotransmitter. Its chemical identities are alkaloid and phthalide-isoquinoline compound. Extracted from plant alkaloid in 1932, this metabolite has been definitively located in Adlumia fungosa, Dicentra cucullaria, Fumariaceae and some species of Corydalis. (+)-Bicuculline acts primarily on ionotropic GABAA receptors but also blocks Ca²⁺-activated potassium channels and can act as an agrochemical.

As a poisonous neurotoxin, it affects nervous system responses associated with GABAA by binding to the receptors but not activating them, thus inhibiting the action of gamma-aminobutyric acid. This produces a powerful convulsive reaction mimicking epilepsy and has been used in lab studies of the condition. Administered with NMDA, it has induced paraplegia. Injection to the amygdala has also produced GABA-related anxiolytic effects on emotional states.

Product Specifications
(+)-Bicuculline
Bicuculline
Bicuculline+

Formula: C₂₀H₁₇NO₆

MW: 367.35 g/mol

Storage/Handling: Store at 4°C.

PubChem Chemical ID: 10237

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Spartein is a class 1a antiarrhythmic agent sodium channel blocker from scotch broom. As a reagent it can be used to synthesize multiple different transformation catalysts and other molecules.

Product Specifications:
Spartein;
Pachycarpine;
Lupinidine

Formula: C₁₅H₂₆N₂

MW: 234.38 g/mol

Storage/Handling: Store at 4°C.

(S)-(+)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid is more commonly known as naproxen. It is a non-steroidal anti-inflammatory agent and non-selective inhibitor of cyclooxygenase (COX-1 and COX-2). Naproxen has been shown to decrease production of thromboxane B2.

Product Specifications:
(S)-(+)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid
Naproxen

Formula: C₁₄H₁₄O₃

MW: 230.26 g/mol

Storage/Handling: Store at room temperature.

1-Benzoylacetone has been used as a 1,3-dicarbonyl compound model for studying keto-enol equilibria in aqueous acid and micellar solutions. Additionally, it has been studied using gas-phase electron diffraction and quantum chemistry.

Product Specifications
1-Benzoylacetone
Acetoacetophenone
1-Phenyl-1,3-butanedione

MOLECULAR BIOLOGY GRADE

Off-white to yellow crystalline powder

Formula: C₁₀H₁₀O₂

MW: 162.19 g/mol

Storage/Handling: Store at -20°C.

Product Specifications: 

Formula: C₅₉H₉₇ClN₂O₄

MW: 933.87 g/mol

Storage/Handling: Store at room temperature.

1,2-Benzoisothiazolin-3-one, sodium salt is an isothiazolinone biocine used in plants and as a preservative. Its mode of action is both fungicidal and microbicidal.

Product Specification: 
1,2-Benzoisothiazolin-3-one, sodium salt

Formula: C₇H₄NNaOS

MW: 173.17 g/mol

Storage/Handling: Store at room temperature.

PubChem ID:13238744

1,2-Bis-(4-pyridyl)ethane is a heterocyclic pyridine used as a building block or ligand to produce hydrogen-bonded adductions. It is used in organic and inorganic chemistry in relation to metals such as copper. It’s been introduced to three-dimensional polymer precursors as an ancillary ligands for probe detection of HIV-1 ds-DNA sequences.

Pronated 1,2-Bis-(4-pyridyl)ethane has been used with ligands to hierarchically produce 2D square grid networks for nanoscale coordination arrays. Other 3D extended networks have been synthesized by incorporating 1,2-Bis-(4-pyridyl)ethane with chemicals like nickel and manganese. These compounds display differing magnetic susceptibility depending on the substance with which 1,2-Bis-(4-pyridyl)ethane is synthesized.

Product Specifications
1,2-Bis-(4-pyridyl)ethane
4,4′-(1,2-Ethanediyl)dipyridine
1,2-Di(4-pyridyl)ethane
4,4′-ethane-1,2-diyldipyridine

Formula: C₁₂H₁₂N₂

MW: 184.24 g/mol

Storage/Handling: Store at room temperature.

PubChem Chemical ID: 78630

1,2-Di-O-octadecyl-rac-glycero-3-phosphocholine is an ether and glycerolipid containing a phosphocholine group. Phosphocholine is an intermediate form produced in tissues during the synthesis of phosphatidylcholine, selectively bonding with some proteins to suppress immune responses as a posttranslational modification. In addition, phosphocoline groups are partly responsible for the CRP recognition and immunologic response that removes damaged cells. 1,2-Di-O-octadecyl-rac-glycero-3-phosphocholine has therefore been used as a reagent and in studies of chemical-cell interactions and glycerophospholipid metabolism.

Product Specifications
1,2-Di-O-octadecyl-rac-glycero-3-phosphocholine
DL-alpha-Dioctadecyllecithin
1,2-Di-O-stearyl-rac-glycero-3-phosphocholine
2,3-Bis(octadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate

Formula: C₄₄H₉₂NO₆P

MW: 762.17 g/mol

Storage/Handling: Store at -20°C.

PubChem Chemical ID:  179555

1,2-Dimyristoyl-sn-glycerol is a carboxylic ester and glycerolipid containing myristic acid side-chains which promotes protein-protein and protein-lipid interactions. It is a saturated diacylglycerol, allowing it to function as a weak second messenger for PKC activation. Other diacylglycerol activities include activating TRPC cation channels 3, 6, and 7; producing prostaglandins; being the precursor to other cellular molecules. It has been applied as a reactant in preparing 1,2-[13,13-2H2]dimyristoyl-sn-glycero-3-phosphoethanolamine and sodium 1,2-ditetradecanoyl-sn-glycer-3-yl phenyl phosphate.

Product Specifications
1,2-Dimyristoyl-sn-glycerol
1,2-Dimyristoyl-L-glycerol
L-1,2-Dimyristin
1,2-Ditetradecanyol-sn-glycerol

Formula: C₃₁H₆₀O₅

MW: 512.82 g/mol

Storage/Handling: Store at -20°C.

PubChem Chemical ID: 10369168

1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine or DPPE is a phospholipid component of the cell membrane. It is used in membrane models and is part of the glycerophosphoethanolamine family. DPPE has been shown to cause competitive hydrogen bonding of amine groups with phosphate/carbonyl groups or water. Additionally, DPPE has been studied along with cholesterol, showing cholesterol’s ability to induce DPPE monolayer condensation when calcium ions are present.

Product Specifications
1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine
Dipalmitoyl-L-alpha-cephalin
1,2-Dihexadecanoyl-sn-glycero-3-phosphoethanolamine

Formula: C₃₇H₇₄NO₈P

MW: 691.980 g/mol

Storage/Handling: Store desiccated at -20°C and protect from light.

1,2-Octanediol has a variety of applications. It is used to improve HPLC separation of organic acids and bases and to synthesize halohydrin palmitates. Additionally, it is studied for its potential use as a pediculicide and has been shown to be effective against louse infestations.

Product Specifications: 
1,2-Octanediol

Formula: C ₈H₁₈O₂

MW: 146.23 g/mol

Storage/Handling: Store at room temperature.

PubChem ID: 14231

1,2,3,4-Tetra-O-acetyl-β-D-glucuronic acid methyl ester has been used in various biochemical studies. It has been used to study the potential of water-soluble camptothecin glucuronide derivatives as a cancer prodrug monotherapy and antibody-directed enzyme prodrug therapy. Additionally, it has been used to assess the role of glycosylthio heterocycles in carbohydrates.

Product Specifications
1,2,3,4-Tetra-O-acetyl-β-D-glucuronic acid methyl ester; 
beta-D-Glucopyranuronic acid, methyl ester, tetraacetate

Formula: C ₁₅H₂₀O₁₁

MW: 376.32 g/mol

Storage/Handling: Protect from light.

1,3-Dilauroyl-glycero-2-phosphocholine is a glycerolipid and carboxylic ester used pharmaceutically. Glycerolipids are groups of fatty acids and glycerol joined with ester bonds. It can function as a human metabolite and acid. This substance also fits the chemical categories of phosphatidylcholine(1+) and quaternary ammonium ions.

Product Specifications
1,3-Dilauroyl-glycero-2-phosphocholine
1,3-Bis(dodecanoyloxy)-2-propanyl 2-(trimethylammonio)ethyl phosphate

Formula: C₃₂H₆₄NO₈P

MW: 621.82 g/mol

Storage/Handling: Store desiccated at -20°C.

1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione is also known as Tanshinone IIA or Dan Shen Ketone. It is an anti-inflammatory, anti-oxidative, and cytotoxic agent. It exhibits cardioprotective properties and has been studied for its potential therapeutic value. Tanshinone IIA has been shown to inhibit LDL oxidation, monocyte adhesion, smooth muscle cell migration, proinflammatory cytokine expression, and platelet accumulation.

Product Specifications:
1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione
Tanshinone IIA
Dan Shen Ketone

Formula: C₁₉H₁₈O₃

MW: 294.34 g/mol

Storage/Handling: Store at 4°C.