Enzyme Inhibitors

Showing 1–16 of 40 results

Product info

Catalog Id
Size
Price
d-410-5
5 g
316.00
d-410-10
10 g
568.00
d-410-25
25 g
1,209.00
d-410-50
50 g
2,178.00
d-410-100
100 g
3,920.00
Description

1-Dodecylimidazole is grouped with the imidazole organic compounds, containing an imidazole 1,3-C3N2 ring produced by natural products like alkaloids. Imidazole is amphoteric and aromatic. When an additional carbon and two hydrogens bind to the ring of this compound, 1-Dodecylimidazole can produce a 1-dodecyl-3-methylimidazolium cation.

As an antifungal, 1-Dodecylimidazole can inhibit sterol C14 demethylation at low levels, 2,3-oxidosqualene cyclization and subsequent transmethylation when the quantity is raised. This has been postulated as a result of its binding to sterol carrier proteins. It functions as a hypocholesterolaemic agent by inhibiting cholesterol biosynthesis at the level of 2,3-oxidosqualene sterol cyclase.

This substance has been an effective antimalarial agent within 15 minutes of administration to in vitro cultures of the pathogen. It exhibited inhibition of protein synthesis and the alkalinization of the parasitic food vacuole. The chemical has also been observed functioning as a lysosomotropic detergent against Saccharomyces cerevisiae.

Product Specifications
1-Dodecylimidazole
N-Dodecylimidazole
1-dodecyl-1H-imidazole

Formula: C15H28N2

MW: 236.40 g/mol

Storage/Handling: Store at 4°C.

PubChem Chemical ID: 78002

Product info

Catalog Id
Size
Price
o-090-250
250 mg
310.00
o-090-500
500 mg
538.00
Description

1-O-Stearyl-2-O-methyl-sn-glycero-3-phosphocholine
Edelfosine

MOLECULAR BIOLOGY GRADE

C27H58NO6P

MW: 523.74 g/mol

Storage/Handling: Store at -15°C, and protect from light.

Product info

Catalog Id
Size
Price
f-440-5
5 g
Description

5-Fluorouracil (5-FU) is a uracil analog that has a fluorine atom on the fifth carbon position. It acts as a strong anti-cancer agent where its metabolization disrupts both RNA and DNA synthesis. 5-FU metabolites, Fluorodeoxyuridine triphosphate (FdUTP) and fluorouridine triphosphate (FUTP), imitate uracil and are incorporated into RNA strands which effectively inhibits further synthesis.

Inhibition of DNA synthesis by 5-FU occurs through thymidylate synthase inhibition. A metabolite produced by 5-FU metabolism, fluorodeoxyuridine triphosphate (FdUTP), bind to the nucleotide binding site of thymidylate synthase. Halting this enzyme’s activity significantly diminishes deoxythymidine monophosphate (dTMP) production which consequently depletes dTMP within an organism.

Product Specifications
5-Fluorouracil
Fluorouracil

Formula: C4H3FN2O2

MW: 130.08 g/mol

Storage/Handling: Store desiccated at room temperature.

PubChem Chemical ID: 3385

Product info

Catalog Id
Size
Price
h-605-100
100 g
104.00
h-605-500
500 g
352.00
Description

8-Hydroxyquinoline is an organic compound that is used as a RNA inhibitor, anti-cancer agent and bidentate chelating agent. In vitro studies against Escherichia coli had shown 8-hydroxyquinoline inhibiting RNA polymerase activity. The enzyme’s activity was inhibited by chelating manganese, magnesium or zinc cofactors. Activity of 8-hydroxyquinoline toward RNA polymerase is broad and inhibits the synthesis of vertebrate RNA as well as proteins.

8-Hydroxyquinoline has also been used as an immobile chelating agent to remove transition metals, alkali and alkaline cations from solutions or within organisms. Its capability to bind the positively charged metals has been shown in vivo to inhibit proteasome activity in tumor cells by transporting copper ions into malignant cells. Halting proteasome activity was observed in vitro and in vivo with decreased cancer growth due to apoptosis.

Product Specifications
8-Hydroxyquinoline

Formula: C9H7NO

MW: 145.16 g/mol

Storage/Handling: Store desiccated at 4°C.

PubChem Chemical ID: 1923

NOT FOR HUMAN USE!!

Product info

Catalog Id
Size
Price
a-415-10
10 mg
Description

Acalabrutinib (ACP-196) is an irreversible inhibitor of Bruton’s tyrosine kinase (BTK), which is responsible for the maturation of B-cells. Its high selectivity to bind the residue Cys481 in the active site of BTK is a sought after feature for oncology research. Studies on mice and human cells demonstrate the high affinity of ACP-196 and its low affinity toward similar proteins in T-cell maturation.

Product Specifications
Acalabrutinib
ACP-196

Formula: C26H23N7O2

MW: 465.51 g/mol

Storage/Handling: Store desiccated at -20°C.

PubChem Chemical ID: 71226662

Product info

Catalog Id
Size
Price
a-910-50
50 mg
Description

Acycloguanosine is a guanosine analogue that is synthetically formed. It is markedly effective against the herpesvirus family, especially HSV (herpes simplex viruses) types one and two. Lab results have shown susceptibility to acycloguanosine which varies with the analogue’s concentration, respective to each virus.

Acycloguanosine functions as a HSV DNA polymerase inhibitor by integrating into the viral DNA, terminating polymerization. Integration occurs after being catalyzed by viral thymidine kinase into acyclovir triphosphate (Acyclo-GTP). Acycloguanosine is ineffective against non-viral genetic material, due to the lack of an appropriate thymidine kinase.

Product Specifications
Acycloguanosine

Formula: C8H11N5O3

MW: 225.20 g/mol

Storage/Handling: Store at room temperature.

PubChem Chemical ID: 2022

NOT FOR HUMAN USE!!

Product info

Catalog Id
Size
Price
a-115-1
1 g
Description

Ampicillin/sulbactam (2:1) is a broad-spectrum combination of a β-lactam antibiotic with a β-lactamase inhibitor. It is used for in vitro susceptibility tests in microbiology, pharmacokinetics and pharmacodynamics studies.

Ampicillin binds to the active site of penicillin binding proteins (PBP), preventing peptidoglycan cross-link formation of the bacterial cell wall. Inhibition of PBPs weakens the bacterial cell wall and leads to cell lysis. Sulbactam irreversibly inhibits β-lactamase enzymes generated by bacteria, preserving ampicillin activity and enhancing potency.

Product Specifications
Ampicillin/sulbactam (2:1)
Sulacillin
Sulbactam-ampicillin mixt.

Formula: C25H31N3O9S2

MW: 581.66 g/mol

Storage/Handling: Store desiccated at -20°C.

PubChem Chemical ID: 119561

Product info

Catalog Id
Size
Price
a-670-100
100 mg
126.00
a-670-500
500 mg
440.00
Description

Artesunate is a synthetic compound that is highly employed for its anti-malarial capabilities and is currently studied for its applications in oncology research and surgical procedures. In anti-malarial studies, it has been shown to disrupt EXP1 activity, which is a glutathione transferase responsible for cell detoxification in Plasmodium falciparum. Artesunate activity has been shown to be enhanced when co-administered with amodiaquine HCl (GoldBio Catalog #A-575).

In oncology research, Artesunate is used to arrest cancer growth in the G2/M phase and upregulate proteins p21 and Beclin1. These proteins are mainly related to apoptosis with p21 being a regulator of the process and Beclin1 playing a role in cell death by autophagy. Artesunate has also been shown to form an endoperoxide bridge which generates carbon radicals that dismantle the cell. However, the observed radical formation is dose and time dependent.

Artesunate has been shown to provide organ damage reduction in rats exposed to hemorrhagic shock. Administration of ART occurred after resuscitation and did not function as a preventative. Artesunate operates by decreasing cell apoptosis through protein kinase B (PKB) stimulation and glycogen synthase kinase inhibition. Cell survival is also enhanced by nuclear factor kappa B (NfkB) suppression, diminishing proinflammatory cytokine synthesis.

Product Specifications
Artesunate
Beta-artesunate

Formula: C19H28O8

MW: 384.42 g/mol

Storage/Handling: Store desiccated at room temperature.
Soluble in ethanol, acetone, chloroform.

PubChem Chemical ID: 65664

NOT FOR HUMAN USE!

Product info

Catalog Id
Size
Price
a-555-10
10 mg
Description

Ascomycin, also known as FK520, is a macrolide immunosuppressant produced by the bacterium Streptomyces hygroscopicus var. ascomyceticus. It is an ethyl analogue of FK506 and is used for post-transplant organ rejection, autoimmune disorders and neurodegeneration.

Ascomycin inhibits T-cell activation and development by binding to calcineurin. Calcineurin is a phosphatase that dephosphorylates nuclear factors of activated T-cells. Calcineurin inhibition prevents production of interleukin 2 (IL2), interleukin 4 (IL4), and the release of cytokines.

Product Specifications
Ascomycin
Immunomycin
FK520

Formula: C43H69NO12

MW: 792.00 g/mol

Storage/Handling: Store desiccated at -20°C.
Soluble in methanol.

PubChem Chemical ID: 5282071

Product info

Catalog Id
Size
Price
b-415-1
1 g
Description

Baicalin is a flavone glycoside formed from the glucuronidation of baicalein. It has an array of properties which include promoting cell survival and bolstering the immune system. One of the effects that baicalin produced with in vitro studies of pathogens and in vivo studies on rats and mice was an elevation in cell survival, which implied the prevention of cell death due to induced apoptosis or the accumulation of oxidative species. Apoptotic repression occurred in rats due to a decreased expression of proteins within the CHOP (C/EBP homologous protein) pathway. Stimulating the synthesis of endothelial nitrogen oxides (eNOS) and other nitrogen oxides quell oxidative stress with the termination of free radicals.

Additionally, protective effects of baicalin have specifically diminished injury in the hippocampal area. Baicalin has been shown to stimulate the expression of Bcl-2 (B-cell lymphoma-2) which regulates apoptosis. It has also been shown to decrease miR-497 expression and cleave caspase-3 protein synthesis. These play roles in regulating gene expression and nervous system cell apoptosis respectively.

Enhancing the immune response with baicalin has proven effective in two ways. One observed effect was the induction of IFN-γ cytokine production in mice, a cytokine which activates macrophages and MHC II (major histocompatibility complex II) expression. Lysozyme bacteriostatic duration was shown to increase when exposed to increasing concentrations of baicalin.

Product Specifications
Baicalin
Baicalein

Formula: C21H18O11

MW: 446.36 g/mol

Storage/Handling: Store desiccated at room temperature.

PubChem Chemical ID: 64982

Product info

Catalog Id
Size
Price
b-700-5
5 mg
Description

Bakuchiol is a terpenophenolic compound extracted from the plant Psoralea corylifolia. Bakuchiol has been used as an oral antibiotic, anti-tumor agent and for the protection of liver and bone tissue. It has also been used as an insulin enhancer to counter hyperglycemia and hyperlipidemia for in vivo research on mice and rats. Within these studies, bakuchiol inhibited phospho-tyrosine protein phosphatase type 1B (PTP1B), DNA polymerase and topoisomerase II. Inactivity of these three enzymes greatly reduced PTPB1 activity, which has been found to suppress insulin signaling.

Antibiotic and anti-tumor uses of bakuchiol have been shown to be correlated to suppression of DNA synthesis. As a bactericidal agent, bakuchiol has been proven to be robust in vitro and is functional at many pH values as well as in the presence of organic acids. Bakuchiol terminates bacteria and malignant cells by generating intracellular reactive oxygen species (ROS), dismantling bacterial cells and compromising tumor cell mitochondria. Conversely, bakuchiol has also been shown to preserve liver function by inhibiting ROS that cause lipid peroxidation and the use of glutathione, an antioxidant.

The bone preserving effects of bakuchiol are related to its high binding affinity for estrogen receptor alpha (ERα). It has been shown that bakuchiol stimulates ERα to promote bone protective pathways.The pathways controlled by ERα increase alkaline phosphatase, calcium concentration, estradiol concentration and a decrease in inorganic phosphate level.

Product Specifications
Bakuchiol
(+)-Bakuchiol

Formula: C18H24O

MW: 256.38 g/mol

Storage/Handling: Store at 4°C.

PubChem Chemical ID: 5468522

Product info

Catalog Id
Size
Price
b-405-10
10 mg
116.00
b-405-100
100 mg
300.00
b-405-250
250 mg
656.00
Description

Bleomycin A5 hydrochloride is a compound part of the glycopeptide antibiotic family. It is currently used in oncology research for its strong stimulatory and inhibitory effects. Bleomycin A5 greatly reduces telomerase activity, hindering the proliferation of malignant cells. It has also been shown to induce in vivo fibrosis and inflammation by generating peroxynitrites, a strong oxidizing agent.

Bleomycin A5 stimulates downstream apoptosis by increasing cysteine-aspartic acid protease-3 (caspase-3) activity, tumor protein 53 (p53) production and transforming growth factor beta 1 (TGF-beta 1) formation. These proteins induce apoptosis directly or indirectly by halting cell growth.

Product Specifications
Bleomycin A5 hydrochloride
Pingyangmycin
1-Bleomycinoic acid hydrochloride

Formula: C57H89N19O21S2

MW: 1477.02 g/mol

Storage/Handling: Store desiccated at 4°C.

PubChem Chemical ID: 84058

Product info

Catalog Id
Size
Price
b-920-500
500 mg
912.00
b-920-1
1 g
1,492.00
b-920-2-5
2.5 g
4,409.00
b-920-5
5 g
4,808.00
Description

Bulbocapnine hydrochloride is the water-soluble form of the bulbocapnine alkaloid group, substances which act as acetylcholinesterase and tyrosine hydroxylase inhibitors. Activity from these chemicals causes dopamine biosynthesis to stall. Bulbocapnine hydrochloride is therefore a dopamine receptor antagonist but has also been used as a tyrosine 3-monooxygenase inhibitor (EC 1.14.16.2) and diamine oxidase inhibitor (EC 1.4.3.22). Because bulbocapnine is a plant metabolite, the substance has been responsible for lethal poisoning in livestock.

Product Specifications
Bulbocapnine hydrochloride
(+)-Bulbocapnine hydrochloride
6aα-Aporphin-11-ol, 10-methoxy-1,2- (methylenedioxy)-, hydrochloride

Formula: C19H20ClNO4

MW: 361.82 g/mol

Storage/Handling: Store at -20°C. Protect from light.

PubChem Chemical ID: 16219195

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Product info

Catalog Id
Size
Price
c-705-50
50 mg
76.00
c-705-100
100 mg
123.00
c-705-250
250 mg
278.00
Description

Camptothecin is an alkaloid compound used as an anti-cancer agent. It is a topoisomerase I inhibitor in DNA synthesis. Camptothecin has been shown to bind and stabilize a topoisomerase I-DNA complex in vitro, preventing the enzyme from reannealing DNA strands. This inhibition specifically effects the S-phase of cell development and ultimately results in apoptosis due to damaged DNA.

Camptothecin is produced by endosymbiotic fungi, from the division Ascomycota (Phycomycete), that are present in the tree Camptotheca acuminata which is native to southern China. Camptothecin (Mappia foetida), (GoldBio Catalog # C-565) has also been isolated from fungi on Mappia foetida (Nothapodytes foetida), a plant common to India.

Product Specifications
Camptothecin (Camptotheca acuminata)

Formula: C20H16N2O4

MW: 348.65 g/mol

Storage/Handling: Store desiccated at 4°C.

PubChem Chemical ID: 24360


Product info

Catalog Id
Size
Price
c-605-50
50 mg
81.00
c-605-100
100 mg
129.00
c-605-250
250 mg
292.00
Description

Camptothecin sodium is sodium salt of an alkaloid compound camptothecin, which is used for cancer research. Camptothecin is produced from endosymbiotic Ascomycota (Phycomycete) fungi present in the tree Camptotheca acuminata or the plant Mappia foetida.

Camptothecin sodium is a topoisomerase I inhibitor in DNA synthesis. It has been shown to bind and stabilize a topoisomerase I-DNA complex in vitro, preventing the enzyme from reannealing DNA strands. This inhibition specifically effects the S-phase of cell development and ultimately results in apoptosis due to damaged DNA.

Product Specifications
Camptothecin sodium
Camptothecin sodium salt
Sodium camptothecin

Formula: C20H17N2NaO5

MW: 388.35 g/mol

Storage/Handling: Store desiccated at room temperature.

PubChem Chemical ID: 23705698

Product info

Catalog Id
Size
Price
c-975-25
25 mg
44.00
c-975-100
100 mg
128.00
c-975-500
500 mg
298.00
Description

Product Specifications
Cantharidin
Cantharidine
Cantharone

Formula: C10H12O4

MW: 196.20 g/mol

Storage/Handling: Store at room temperature.

Soluble in DMSO and ethanol.

PubChem Chemical ID: 5944