EGF

Showing all 12 results

Product info

Catalog Id
Size
Price
1150-11-10
10 μg
117.00
1150-11-50
50 μg
172.00
1150-11-1000
1000 μg
1,206.00
1150-11-250
448.00
1150-11-500
674.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Human Amphiregulin
Amphiregulin B (AREGB)
Schwannoma-derived Growth Factor (SDGF)

AREG (Amphiregulin) is an EGF related growth factor containing 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds essential for biological activity. It was originally isolated from the MCF-7 human breast carcinoma cell line and is expressed in numerous carcinoma cell lines, as well as the epithelial cells of various human tissues including colon, stomach, breast, ovary, and kidney. AREG participates in autocrine signaling and binds to an EGF/TGF-α receptor, stimulating growth of keratinocytes, epithelial cells and some fibroblasts. It also inhibits the growth of certain carcinoma cell lines. It is synthesized as a transmembrane protein and the ectodomain is cleaved by a protease to release the mature protein. Overexpression of AREG produces a cutaneous phenotype resembling psoriasis.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source:Escherichia coli

MW: ~11.3 kDa (98 amino acids)

Purity: >95% by SDS-PAGE and HPLC analyses.

Storage/Handling: Store desiccated at -20°C.

HGNC: 651

NOT FOR HUMAN USE!

Additional resources for this protein may be found at:
OMIM

Product info

Catalog Id
Size
Price
1170-12-5
5 μg
117.00
1170-12-20
20 μg
172.00
1170-12-1000
1000 μg
2,220.00
1170-12-250
896.00
1170-12-500
1,390.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Human Betacellulin (BTC)
BCN

BTC (Betacellulin) is an EGF related growth factor containing 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds essential for biological activity. It was originally isolated from the MCF-7 human breast carcinoma cell line and it is expressed in most tissues including kidney, uterus, liver and pancreas. BTC is also present in body fluids, including serum, milk, and colostrum. BTC is a ligand for the receptors erbB1 and erbB4. It is synthesized as a transmembrane protein and the ectodomain is cleaved by a protease to release the mature protein. BTC exhibits mitogenic activity for retinal pigment epithelial cells and vascular smooth muscle cells. It also exhibits growth-promoting activity that is similar to that of EGF.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~9.0 kDa (80 amino acids)

Purity: >98% by SDS-PAGE and HPLC analyses

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 0.05 ng/ml, corresponding to a specific activity of >2.0×107 IU/mg.

Storage/Handling: Store desiccated at -20°C.

HGNC: 1121

NOT FOR HUMAN USE!

Additional resources for this protein may be found at:
OMIM

Product info

Catalog Id
Size
Price
1370-12-5
5 μg
117.00
1370-12-20
20 μg
172.00
1370-12-1000
1000 μg
2,220.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Murine Betacellulin (BTC)
BCN

BTC (Betacellulin) is an EGF related growth factor containing 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds essential for biological activity. It was originally isolated from the MCF-7 human breast carcinoma cell line and it is expressed in most tissues including kidney, uterus, liver and pancreas. BTC is also present in body fluids, including serum, milk, and colostrum. BTC is a ligand for the receptors erbB1 and erbB4. It is synthesized as a transmembrane protein and the ectodomain is cleaved by a protease to release the mature protein. BTC exhibits mitogenic activity for retinal pigment epithelial cells and vascular smooth muscle cells. It also exhibits growth-promoting activity that is similar to that of EGF.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~9.0 kDa (80 amino acids)

Purity: >96% by SDS-PAGE and HPLC analyses

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 0.01 ng/ml, corresponding to a specific activity of >1.0×108 IU/mg.

Storage/Handling: Store desiccated at -20°C.

MGI: 99439

NOT FOR HUMAN USE!

Additional resources for this protein may be found at:
OMIM

Product info

Catalog Id
Size
Price
1150-04-100
100 μg
86.00
1150-04-500
500 μg
111.00
1150-04-1000
1000 μg
123.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Human Epidermal Growth Factor
EGF
HMGF (Human Milk Growth Factor)
PGF (Prostatic Growth Factor)

EGF (Epidermal Growth Factor) is a family of growth factors that are derived from membrane-anchored precursors. The family is characterized by the presence of at least one “EGF-like domain” (characterized by the presence of three disulfide bonds, formed from 6 conserved cysteine residues) in their extracellular domain. EGF was originally discovered as an activity that induced early eyelid opening, incisor eruption, hair growth inhibition and stunting of growth when injected into newborn mice. Mature human EGF shares 70% amino acid sequence identity with mature mouse and rat EGF. Human EGF was isolated from urine based on its inhibitory effect on gastric secretion and is sometimes called urogastrone.

Formulation: Sterile filtered white lyophilized powder. Purified and tested for use in cell culture.

Sequence: NSDSECPLSH DGYCLHDGVC MYIEALDKYA CNCVVGYIGE RCQYRDLKWW ELR

MW: ~6.2 kDa (53 amino acid)

Purity: >98% by SDS-PAGE and HPLC analyses

Biological activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine BALB/c 3T3 cells is less than 1 ng/ml, corresponding to a specific activity of >1.0×106 IU/mg.

Accession Number: P01133

HGNC ID: 3229

Source: Escherichia coli

Storage/Handling: This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage. The reconstituted sample can be apportioned into working aliquots and stored at -80 °C for up to 6 months. Avoid repeated freeze/thaw cycles.

Reconstitution: The sample should be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in a siliconized tube using PBS that contains a 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Reconstituted solutions are stable for up to one week at 2-8°C. Stock solutions should be aliquoted and stored at -80°C. Further dilutions should be made in appropriate buffered solutions.

Additional resources for this product may be found at:

OMIM

NOT FOR HUMAN USE!


Product info

Catalog Id
Size
Price
1350-04-100
100 μg
117.00
1350-04-500
500 μg
172.00
1350-04-1000
1000 μg
208.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Murine Epidermal Growth Factor
EGF
HMGF (Human Milk Growth Factor)
PGF (Prostatic Growth Factor)

EGF (Epidermal Growth Factor) is a family of growth factors that are derived from membrane-anchored precursors. The family is characterized by the presence of at least one “EGF-like domain” (characterized by the presence of three disulfide bonds, formed from 6 conserved cysteine residues) in their extracellular domain. EGF was originally discovered as an activity that induced early eyelid opening, incisor eruption, hair growth inhibition and stunting of growth when injected into newborn mice. Additionally, EGF has been shown to inhibit gastric secretion, is involved in wound healing and signals through a receptor known as c-erbB (a class I tyrosine kinase receptor).

Formulation: Sterile filtered white lyophilized powder. Purified and tested for use in cell culture.

Sequence: NSYPGCPSSY DGYCLNGGVC MHIESLDSYT CNCVIGYSGD RCQTRDLRWW ELR

MW: ~6.0 kDa (53 amino acid)

Purity: >97% by SDS-PAGE and HPLC analyses

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay murine BSLB/c 3T3 cells is less than 0.1 ng/ml, corresponding to a specific activity of >1.0 × 107 IU/mg.

Accession Number: P01132

MGI ID: 95290

Source: Escherichia coli

Storage/Handling: This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage. The reconstituted sample can be apportioned into working aliquots and stored at -80 °C for up to 6 months. Avoid repeated freeze/thaw cycles.

Reconstitution: The sample should be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in a siliconized tube using PBS that contains a 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Reconstituted solutions are stable for up to one week at 2-8°C. Stock solutions should be aliquoted and stored at -80°C. Further dilutions should be made in appropriate buffered solutions containing BSA or serum.

Additional resources for this product may be found at:

OMIM

NOT FOR HUMAN USE!


Product info

Catalog Id
Size
Price
1550-04-20
20 μg
117.00
1550-04-100
100 μg
172.00
1550-04-250
336.00
1550-04-500
532.00
1550-04-1000
933.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Rat Epidermal Growth Factor
EGF
HMGF (Human Milk Growth Factor)
PGF (Prostatic Growth Factor)

EGF (Epidermal Growth Factor) is a family of growth factors that are derived from membrane-anchored precursors. The family is characterized by the presence of at least one “EGF-like domain” (characterized by the presence of three disulfide bonds, formed from 6 conserved cysteine residues) in their extracellular domain. EGF was originally discovered as an activity that induced early eyelid opening, incisor eruption, hair growth inhibition and stunting of growth when injected into newborn mice. Additionally, EGF has been shown to inhibit gastric secretion, is involved in wound healing and signals through a receptor known as c-erbB (a class I tyrosine kinase receptor).

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~6.2 kDa (54 amino acid)

Purity: >97% by SDS-PAGE and HPLC analyses

Storage/Handling: Store desiccated at -20°C.

Rat Genome Database ID: 2542

NOT FOR HUMAN USE!

Cross-species homology


Percent Similarity

Additional resources for this protein may be found at:
OMIM

Note: 1000 µg volume may be delivered in multiple containers.

Product info

Catalog Id
Size
Price
1150-06-5
5 μg
117.00
1150-06-25
25 μg
172.00
1150-06-1000
1000 μg
2,220.00
1150-06-250
896.00
1150-06-500
1,390.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Human Epithelial Mitogen
Epigen
EPG
ALGV2072
PRO9904

EPGN is a member of the epidermal growth factor family and expression has been seen in several tissues, including the testis, liver, heart and certain tumor cells. It is a strong mitogen for fibroblasts and epithelial cells but has low affinity for its main receptor, ErbB1. The enhanced mitogenic potential is attributed to inefficient receptor ubiquitylation and endocytosis. EPGN stimulates phosphorylation of c- erbB-1 and MAP kinases in epithelial cells. The protein contains a conserved sequence of six cysteine residues and two N-linked glycosylation sites, with two hydrophobic regions comprised of a signal sequence and a transmembrane domain. Alternative splicing of the EPGN gene results in multiple isoforms.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~7.9 kDa (72 amino acids)

Purity: >98 % by SDS-PAGE and HPLC analyses

Storage/Handling:Store desiccated at -20°C.

HGNC: 17470

NOT FOR HUMAN USE!


Product info

Catalog Id
Size
Price
1150-07-5
5 μg
117.00
1150-07-25
25 μg
172.00
1150-07-1000
1000 μg
2,220.00
1150-07-250
896.00
1150-07-500
1,390.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Human Epiregulin
EREG
ER

EREG is a member of the epidermal growth factor (EGF) family and is expressed mainly in the placenta and peripheral blood leukocytes, as well as in certain carcinomas of the bladder, lung, kidney, and colon. EREG stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. Additionally, it inhibits the growth of several tumor-derived epithelial cell lines. EREG is synthesized as a transmembrane protein and the ectodomain is cleaved by a protease to release the mature protein. The mature protein can bind to EGFR, as well as most members of the ERBB family of RTKs.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~5.6 kDa (49 amino acids)

Purity: >97% by SDS-PAGE and HPLC analyses

Biological Activities: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 2 ng/ml, corresponding to a specific activity of >5.0×105 IU/mg.

Storage/Handling:Store desiccated at -20°C.

HGNC: 3443

NOT FOR HUMAN USE!

Additional resources for this protein may be found at:
OMIM

Product info

Catalog Id
Size
Price
1150-14-10
10 μg
117.00
1150-14-50
50 μg
172.00
1150-14-1000
1000 μg
1,206.00
1150-14-250
448.00
1150-14-500
674.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Human Heparin-binding EGF-like Growth Factor
Heparin-binding EGF
HEGFL
Diphtheria Toxin Receptor (DTR)

Heparin-binding epidermal growth factor-like growth factor (HBEGF) is synthesized as a transmembrane precursor that is cleaved by a protease to release HBEGF as the ectodomain. Its expression stimulates neurogenesis and is increased after the brain experiences cerebral hypoxia. HBEGF is known to participate in a variety of normal physiological processes such as blastocyst implantation and wound healing, as well as in pathological processes such as tumor growth, SMC hyperplasia and atherosclerosis. HBEGF is a glycoprotein exhibiting mitogenic and chemotactic activity in smooth muscle cells and fibroblasts.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source:Escherichia coli

MW: ~9.7 kDa (86 amino acids)

Purity: >97% by SDS-PAGE and HPLC analyses.

Storage/Handling: Store desiccated at -20°C.

HGNC: 3059

NOT FOR HUMAN USE!

Additional resources for this protein may be found at:
OMIM

Product info

Catalog Id
Size
Price
1350-08-10
10 μg
117.00
1350-08-50
50 μg
172.00
1350-08-1000
1000 μg
1,206.00
1350-08-250
448.00
1350-08-500
674.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Murine Heparin-binding EGF-like Growth Factor
Heparin-binding EGF
HEGFL
Diphtheria Toxin Receptor (DTR)

Heparin-binding epidermal growth factor-like growth factor (HBEGF) is synthesized as a transmembrane precursor that is cleaved by a protease to release HBEGF as the ectodomain. Its expression stimulates neurogenesis and is increased after the brain experiences cerebral hypoxia. HBEGF is known to participate in a variety of normal physiological processes such as blastocyst implantation and wound healing, as well as in pathological processes such as tumor growth, SMC hyperplasia and atherosclerosis. HBEGF is a glycoprotein exhibiting mitogenic and chemotactic activity in smooth muscle cells and fibroblasts.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source:Escherichia coli

MW: ~9.7 kDa (86 amino acids)

Purity: >97% by SDS-PAGE and HPLC analyses.

Storage/Handling: Store desiccated at -20°C.

Mouse Genome Database ID: 96070

NOT FOR HUMAN USE!

Additional resources for this protein may be found at:
OMIM

Product info

Catalog Id
Size
Price
1550-08-10
10 μg
117.00
1550-08-50
50 μg
172.00
1550-08-1000
1000 μg
1,206.00
1550-08-250
448.00
1550-08-500
674.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Rat Heparin-binding EGF-like Growth Factor
Heparin-binding EGF
HEGFL
Diphtheria Toxin Receptor (DTR)

Heparin-binding epidermal growth factor-like growth factor (HBEGF) is synthesized as a transmembrane precursor that is cleaved by a protease to release HBEGF as the ectodomain. Its expression stimulates neurogenesis and is increased after the brain experiences cerebral hypoxia. HBEGF is known to participate in a variety of normal physiological processes such as blastocyst implantation and wound healing, as well as in pathological processes such as tumor growth, SMC hyperplasia and atherosclerosis. HBEGF is a glycoprotein exhibiting mitogenic and chemotactic activity in smooth muscle cells and fibroblasts.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source:Escherichia coli

MW: ~9.7 kDa (86 amino acids)

Purity: >95% by SDS-PAGE and HPLC analyses.

Storage/Handling: Store desiccated at -20°C.

Rat Genome Database ID: 2526

NOT FOR HUMAN USE!

Additional resources for this protein may be found at:
OMIM

Product info

Catalog Id
Size
Price
1150-41-20
20 μg
Description