FGF

Showing 1–16 of 25 results

Product info

Catalog Id
Size
Price
1140-01-10
10 μg
70.00
1140-01-50
50 μg
110.00
1140-01-1000
1000 μg
921.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption! 

Recombinant Human Fibroblast Growth Factor 1
FGF1, aFGF
Acidic FGF
Endothelial cell growth factor

FGF1 is a member of the Fibroblast Growth Factor family of proteins. Also called FGF-acidic or aFGF, FGF1 lacks signal peptides and is believed to be secreted by a nonclassical mechanism. It has been detected in large amounts in the brain and is expressed in hepatocyte cells, vascular smooth muscle cells, CNS neurons, skeletal muscle cells, fibroblasts, keratinocytes, endothelial cells, intestinal columnar epithelial cells, and pituitary basophils and acidophils. FGF1 exhibits considerable species cross-reactivity and stimulates the proliferation of cells of mesodermal origin, as well as many cells of neuroectodermal, ectodermal, and endodermal origin. It is most closely associated with FGF2 (bFGF) (see additional information).

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~15.8 kDa (141 amino acids)

Purity: >95% by SDS-PAGE and HPLC analyses

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine balb/c 3T3 cells is less than 0.5 ng/ml, corresponding to a specific activity of >2.0×106 IU/mg in the presence of 10 μg/ml of heparin.

Storage/Handling: Store desiccated at -20°C.

HGNC ID: 3665

NOT FOR HUMAN USE!

Cross-species homology
Percent Similarity
HuaFGF MuaFGF
HuaFGF *** 96.5
MuaFGF *** ***

Additional resources for this protein may be found at:
OMIM

Product info

Catalog Id
Size
Price
1340-01-10
10 μg
70.00
1340-01-50
50 μg
110.00
1340-01-1000
1000 μg
921.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Murine Fibroblast Growth Factor 1
FGF1, aFGF
Acidic FGF
Endothelial cell growth factor

FGF1 is a member of the Fibroblast Growth Factor family of proteins. Also called FGF-acidic or aFGF, FGF1 lacks signal peptides and is believed to be secreted by a nonclassical mechanism. It has been detected in large amounts in the brain and is expressed in hepatocyte cells, vascular smooth muscle cells, CNS neurons, skeletal muscle cells, fibroblasts, keratinocytes, endothelial cells, intestinal columnar epithelial cells and pituitary basophils and acidophils. FGF1 exhibits considerable species cross-reactivity and stimulates the proliferation of cells of mesodermal origin as well as many cells of neuroectodermal, ectodermal, and endodermal origin. It is most closely associated with FGF2 (bFGF) (see additional information).

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~15.9 kDa (141 amino acids)

Purity: >95% by SDS-PAGE and HPLC analyses

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine balb/c 3T3 cells is less than 0.2 ng/ml, corresponding to a specific activity of >5.0×106 IU/mg in the presence of 10 μg/ml of heparin.

Storage/Handling: Store desiccated at -20°C.

Mouse Genome Database ID: 95515

NOT FOR HUMAN USE!

Cross-species homology
Percent Similarity
HuaFGF MuaFGF
HuaFGF *** 96.5
MuaFGF *** ***

Additional resources for this protein may be found at:
OMIM

Note: 1000 µg volume may be delivered in multiple containers.

Product info

Catalog Id
Size
Price
1640-02-10
10 μg
70.00
1640-02-50
50 μg
110.00
1640-02-1000
1000 μg
921.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Bovine Fibroblast Growth Factor 2
Fibroblast Growth Factor-basic
bFGF, FGF-2
Basic FGF

FGF2 is a member of the fibroblast growth factor family of proteins. It is often called FGF-basic or bFGF. FGF2 is a single-chain polypeptide growth factor that plays a significant role in wound healing, it is a potent inducer of angiogenesis and it is essential for the growth of many stem and progenitor cells. FGF2 shares a 55% amino acid residue identity with FGF1 and interacts with heparin sulfate with nanomolar affinity. It is a potent inducer of DNA synthesis in a variety of cell types. FGF2 activates mesenchymal splice variants of FGF receptors (c splice variants) and also activates FGF Receptor 1b, but has little activity against FGFR2b or FGFR3b. It is most closely associated with FGF1 (aFGF) (see additional information).

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~16.5 kDa (147 amino acids)

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine balb/c 3T3 cells is less than 0.1 ng/ml, corresponding to a specific activity of >1.0×107 IU/mg.

Purity: >97% by SDS-PAGE and HPLC analyses.

Storage/Handling: Store desiccated at -20°C.

NCBI: 281161

NOT FOR HUMAN USE!

Additional resources for this protein may be found at:
OMIM

Product info

Catalog Id
Size
Price
1140-02-10
10 μg
70.00
1140-02-50
50 μg
110.00
1140-02-1000
1000 μg
879.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Human Fibroblast Growth Factor 2
Fibroblast Growth Factor-basic
bFGF, FGF-2
basic FGF

FGF2 is a member of the fibroblast growth factor family of proteins. It is often called FGF-basic or bFGF. FGF2 is a single-chain polypeptide growth factor that plays a significant role in wound healing, it is a potent inducer of angiogenesis and it is essential for the growth of many stem and progenitor cells. FGF2 shares a 55% amino acid residue identity with FGF1 and interacts with heparin sulfate with nanomolar affinity. It is a potent inducer of DNA synthesis in a variety of cell types. FGF2 activates mesenchymal splice variants of FGF receptors (c splice variants) and also activates FGF Receptor 1b, but has little activity against FGFR2b or FGFR3b. It is most closely associated with FGF1 (aFGF) (see additional information).

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~16.5 kDa (147 amino acids)

Purity: >96% by SDS-PAGE and HPLC analyses

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine balb/c 3T3 cells is less than 0.05 ng/ml, corresponding to a specific activity of >2.0×107 IU/mg.

Store desiccated at -20°C.

HGNC ID: 3676

NOT FOR HUMAN USE!

Cross-species homology
Percent Similarity
HubFGF MubFGF RtbFGF
HubFGF *** 97.3 96.6
MubFGF *** *** 98.6
RtbFGF *** *** ***

Additional resources for this protein may be found at:
OMIM

Product info

Catalog Id
Size
Price
1340-02-10
10 μg
70.00
1340-02-50
50 μg
110.00
1340-02-1000
1000 μg
862.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Murine Fibroblast Growth Factor 2
Fibroblast Growth Factor-basic
bFGF, FGF-2
basic FGF

FGF2 is a member of the Fibroblast Growth Factor family of proteins. It is often called FGF-basic or bFGF. FGF2 is a single-chain polypeptide growth factor that plays a significant role in wound healing, it is a potent inducer of angiogenesis and it is essential for the growth of many stem and progenitor cells. FGF2 shares a 55% amino acid residue identity with FGF1 and interacts with heparin sulfate with nanomolar affinity. It is a potent inducer of DNA synthesis in a variety of cell types. FGF2 activates mesenchymal splice variants of FGF receptors (c splice variants) and also activates FGF Receptor 1b, but has little activity against FGFR2b or FGFR3b. It is most closely associated with FGF1 (aFGF) (see additional information).

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~16.2 kDa (146 amino acids)

Purity: >98% by SDS-PAGE and HPLC analyses

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine balb/c 3T3 cells is less than 1.0 ng/ml, corresponding to a specific activity of >1.0×106 IU/mg.

Storage/Handling: Store desiccated at -20°C.

Mouse Genome Database ID: 95516

NOT FOR HUMAN USE!

Cross-species homology
Percent Similarity
HubFGF MubFGF RtbFGF
HubFGF *** 97.3 96.6
MubFGF *** *** 98.6
RtbFGF *** *** ***

Additional resources for this protein may be found at:
OMIM

Product info

Catalog Id
Size
Price
1540-02-10
10 μg
70.00
1540-02-50
50 μg
110.00
1540-02-1000
1000 μg
1,056.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Rat Fibroblast Growth Factor 2
Fibroblast Growth Factor-basic
bFGF, FGF-2
basic FGF

FGF2 is a member of the Fibroblast Growth Factor family of proteins. It is often called FGF-basic or bFGF. FGF2 is a single-chain polypeptide growth factor that plays a significant role in wound healing, it is a potent inducer of angiogenesis and it is essential for the growth of many stem and progenitor cells. FGF2 shares a 55% amino acid residue identity with FGF1 and interacts with heparin sulfate with nanomolar affinity. It is a potent inducer of DNA synthesis in a variety of cell types. FGF2 activates mesenchymal splice variants of FGF receptors (c splice variants) and also activates FGF Receptor 1b, but has little activity against FGFR2b or FGFR3b. It is most closely associated with FGF1 (aFGF) (see additional information).

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~16.3 kDa (145 amino acids)

Purity: >98% by SDS-PAGE and HPLC analyses

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine balb/c 3T3 cells is less than 0.2 ng/ml, corresponding to a specific activity of >5.0×106 IU/mg.

Storage/Handling: Store desiccated at -20°C.

Rat Genome Database ID: 2609

NOT FOR HUMAN USE!

Cross-species homology
Percent Similarity
HubFGF MubFGF RtbFGF
HubFGF *** 97.3 96.6
MubFGF *** *** 98.6
RtbFGF *** *** ***

Additional resources for this protein may be found at:
OMIM

Product info

Catalog Id
Size
Price
1140-10-5
5 μg
99.00
1140-10-25
25 μg
153.00
1140-10-1000
1000 μg
1,941.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Human Fibroblast Growth Factor 10
FGF10
KGF2
Keratinocyte Growth Factor 2

FGF10/KGF2 is a member of the Fibroblast Growth Factor family of proteins. KGF2 cDNA encodes a 208 amino acid residue protein with a hydrophobic amino-terminal signal peptide. Human KGF2 shares 92% and 95% amino acid sequence identity with mouse and rat KGF2, respectively. In the FGF family, KGF2 is most closely related to FGF7 (KGF1), FGF3 and FGF22 (see additional information). The expression of KGF2 transcript has been shown to be most abundant in the embryo and adult lung. Recombinant KGF2 has been shown to be mitogenic for epithelial and epidermal cells but not fibroblasts. KGF2 may play unique roles in brain and lung development, wound healing and limb bud formation.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~19.3 kDa (170 amino acids)

Purity: >96% by SDS-PAGE and HPLC analyses

Storage/Handling: Store desiccated at -20°C.

HGNC ID: 3666

NOT FOR HUMAN USE!

Cross-species homology
Percent Similarity
HuFGF10 MuFGF10 RtFGF10
HuFGF10 *** 93.1 95.5
MuFGF10 *** *** 90.5
RtFGF10 *** *** ***

Additional resources for this protein may be found at:
OMIM

Product info

Catalog Id
Size
Price
1340-10-5
5 μg
99.00
1340-10-25
25 μg
153.00
1340-10-1000
1000 μg
2,304.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Murine Fibroblast Growth Factor 10
FGF10
KGF2
Keratinocyte Growth Factor 2

FGF10/KGF2 is a member of the Fibroblast Growth Factor family of proteins. KGF2 cDNA encodes a 208 amino acid residue protein with a hydrophobic amino-terminal signal peptide. Human KGF2 shares 92% and 95% amino acid sequence identity with mouse and rat KGF2, respectively. In the FGF family, KGF2 is most closely related to FGF7 (KGF1), FGF3 and FGF22 (see additional information). The expression of KGF2 transcript has been shown to be most abundant in the embryo and adult lung. Recombinant KGF2 has been shown to be mitogenic for epithelial and epidermal cells but not fibroblasts. KGF2 may play unique roles in brain and lung development, wound healing and limb bud formation.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~19.3 kDa (173 amino acids)

Purity: >95% by SDS-PAGE and HPLC analyses

Storage/Handling: Store desiccated at -20°C.

Mouse Genome Database ID: 1099809

NOT FOR HUMAN USE!

Cross-species homology
Percent Similarity
HuFGF10 MuFGF10 RtFGF10
HuFGF10 *** 93.1 95.5
MuFGF10 *** *** 90.5
RtFGF10 *** *** ***

Additional resources for this protein may be found at:
OMIM

Product info

Catalog Id
Size
Price
1540-10-5
5 μg
99.00
1540-10-25
25 μg
153.00
1540-10-1000
1000 μg
2,304.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Rat Fibroblast Growth Factor 10
FGF10
KGF2
Keratinocyte Growth Factor 2

FGF10/KGF2 is a member of the Fibroblast Growth Factor family of proteins. KGF2 cDNA encodes a 208 amino acid residue protein with a hydrophobic amino-terminal signal peptide. Human KGF2 shares 92% and 95% amino acid sequence identity with mouse and rat KGF2, respectively. In the FGF family, KGF2 is most closely related to FGF7 (KGF1), FGF3 and FGF22 (see additional information). The expression of KGF2 transcript has been shown to be most abundant in the embryo and adult lung. Recombinant KGF2 has been shown to be mitogenic for epithelial and epidermal cells but not fibroblasts. KGF2 may play unique roles in brain and lung development, wound healing and limb bud formation.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~20.0 kDa (179 amino acids)

Purity: >96% by SDS-PAGE and HPLC analyses

Storage/Handling: Store desiccated at -20°C.

Rat Genome Database ID: 2606

NOT FOR HUMAN USE!

Cross-species homology
Percent Similarity
HuFGF10 MuFGF10 RtFGF10
HuFGF10 *** 93.1 95.5
MuFGF10 *** *** 90.5
RtFGF10 *** *** ***

Additional resources for this protein may be found at:
OMIM

Product info

Catalog Id
Size
Price
1140-13-5
5 μg
99.00
1140-13-20
20 μg
153.00
1140-13-1000
1000 μg
2,304.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Human Fibroblast Growth Factor 13
Fibroblast Growth Factor Homologous Factor 2 (FHF2)
FGF-13

FGF13 is a member of the Fibroblast Growth Factor family of proteins. It is one of four FGFs that act as intracellular signaling molecules, independent of FGF receptors. They have instead been shown to interact with voltage-gated ion channels and the MAPK scaffold protein, islet-brain 2. FGF13 is expressed in the developing and adult central nervous system and acts to stabilize microtubules. It is required for axon and leading process development, as well as neuronal migration. It is believed to be a candidate gene for syndromal and nonspecific forms of X-chromosome-linked intellectual disability (XLID).

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~27.6 kDa (245 amino acids)

Purity: >95% by SDS-PAGE and HPLC analyses

Storage/Handling: Store desiccated at -20°C.

HGNC: 3670

NOT FOR HUMAN USE!

Additional resources for this protein may be found at:
OMIM

Product info

Catalog Id
Size
Price
1140-18-5
5 μg
99.00
1140-18-25
25 μg
153.00
1140-18-1000
1000 μg
2,304.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Human Fibroblast Growth Factor 18
FGF18

FGF18 is a member of the Fibroblast Growth Factor family of proteins. FGF18 has been shown in vitro to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggest that this protein is a pleiotropic growth factor that stimulates proliferation in tissues such as the liver and small intestine. FGF18 acts as a trophic factor for elastic chondrocytes in vivo and articular chondrocytes cultured in vitro and plays an autocrine role in normal articular cartilage repair. It is most closely related to FGF8 and FGF17 (see additional information).

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~21.1 kDa (181 amino acids)

Purity: >97% by SDS-PAGE and HPLC analyses

Storage/Handling: Store desiccated at -20°C.

HGNC ID: 3674

NOT FOR HUMAN USE!

Cross-species homology
Percent Similarity
HuFGF18 MuFGF18 RtFGF18
HuFGF18 *** 98.9 98.3
MuFGF18 *** *** 99.4
RtFGF18 *** *** ***

Additional resources for this protein may be found at:
OMIM

Product info

Catalog Id
Size
Price
1340-18-5
5 μg
99.00
1340-18-25
25 μg
153.00
1340-18-1000
1000 μg
2,304.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Murine Fibroblast Growth Factor 18
FGF-18

FGF18 is a member of the Fibroblast Growth Factor family of proteins. FGF18 has been shown in vitro to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggest that this protein is a pleiotropic growth factor that stimulates proliferation in tissues such as the liver and small intestine. FGF18 acts as a trophic factor for elastic chondrocytes in vivo and articular chondrocytes cultured in vitro and plays an autocrine role in normal articular cartilage repair. FGF18 –/– mice have decreased expression of osteogenic markers and delayed long-bone ossification. FGF18 has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. It is most closely related to FGF8 and FGF17 (see additional information).

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~21.0 kDa (180 amino acid)

Purity: >95% by SDS-PAGE and HPLC analyses

Storage/Handling: Store desiccated at -20°C.

NOT FOR HUMAN USE!

MGI: 1277980

Cross-species homology
Percent Similarity
HuFGF18 MuFGF18 RtFGF18
HuFGF18 *** 98.9 98.3
MuFGF18 *** *** 99.4
RtFGF18 *** *** ***

Additional resources for this protein may be found at:
OMIM

Product info

Catalog Id
Size
Price
1540-18-5
5 μg
99.00
1540-18-25
25 μg
153.00
1540-18-1000
1000 μg
2,304.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Rat Fibroblast Growth Factor 18
FGF18

FGF18 is a member of the Fibroblast Growth Factor family of mitogenic proteins. FGF18 has been shown in vitro to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggest that this protein is a pleiotropic growth factor that stimulates proliferation in tissues such as the liver and small intestine. FGF18 acts as a trophic factor for elastic chondrocytes in vivo and articular chondrocytes cultured in vitro and plays an autocrine role in normal articular cartilage repair. It is most closely related to FGF8 and FGF17 (see additional information).

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~21.0 kDa (180 amino acids)

Purity: >95% by SDS-PAGE and HPLC analyses

Storage/Handling: Store desiccated at -20°C.

Rat Genome Database ID: 2608

NOT FOR HUMAN USE!

Cross-species homology
Percent Similarity
HuFGF18 MuFGF18 RtFGF18
HuFGF18 *** 98.9 98.3
MuFGF18 *** *** 99.4
RtFGF18 *** *** ***

Additional resources for this protein may be found at:
OMIM

Product info

Catalog Id
Size
Price
1140-19-5
5 μg
99.00
1140-19-25
25 μg
153.00
1140-19-1000
1000 μg
2,304.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Human Fibroblast Growth Factor 19
FGF15/19
FGF-19

FGF19 is a member of the Fibroblast Growth Factor family of proteins. It is in the same endocrine signaling subfamily as FGF21 and FGF23 and is the human ortholog of mouse FGF15. FGF19 is a heparin-dependent ligand and binds exclusively to FGFR4. It is essential for brain and heart development, as well as the metabolism of bile acid, hepatic protein, and glycogen. FGF19 mRNA is expressed in several tissues including fetal cartilage, skin, and retina, as well as adult gall bladder and is overexpressed in a colon adenocarcinoma cell line.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~21.8 kDa (195 amino acids)

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 150 ng/ml, corresponding to a specific activity of >6.7×103 IU/mg.

Purity: >95% by SDS-PAGE and HPLC analyses

Storage/Handling: Store desiccated at -20°C.

HGNC: 3675

NOT FOR HUMAN USE!

Additional resources for this protein may be found at:
OMIM

Product info

Catalog Id
Size
Price
1140-21-5
5 μg
99.00
1140-21-25
25 μg
153.00
1140-21-1000
1000 μg
2,304.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Human Fibroblast Growth Factor 21
FGF-21

FGF21 is a member of the Fibroblast Growth Factor family of proteins. It is in the same endocrine signaling subfamily as FGF19 and FGF23. FGF21 is a heparin-binding ligand for FGFR1c and FGFR4 that requires the presence of beta-klotho. Expression of FGF21 mRNA has been observed in the liver, the thymus, and several types of adipose tissue. It has been shown to stimulate glucose incorporation in differentiated adipocytes, independent of insulin activity. It has been suggested that FGF21 also acts as key regulator in the adaptation to stress.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~19.4 kDa (181 amino acids)

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by thymidine uptake assay using FGF-receptors transfected BaF3 cells is less than 0.5 μg/ml, corresponding to a specific activity of >2.0×103 IU/mg in the presence of 5 µg/ml of rMuKlotho-β and 10 μg/ml of heparin.

Purity: >95% by SDS-PAGE and HPLC analyses

Storage/Handling: Store desiccated at -20°C.

HGNC: 3678

NOT FOR HUMAN USE!

Additional resources for this protein may be found at:
OMIM

Product info

Catalog Id
Size
Price
1340-21-5
5 μg
99.00
1340-21-25
25 μg
153.00
1340-21-1000
1000 μg
2,304.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Murine Fibroblast Growth Factor 21
FGF-21

FGF21 is a member of the Fibroblast Growth Factor family of proteins. It is in the same endocrine signaling subfamily as FGF19 and FGF23. FGF21 is a heparin-binding ligand for FGFR1c and FGFR4 that requires the presence of beta-klotho. Expression of FGF21 mRNA has been observed in the liver, the thymus, and several types of adipose tissue. It has been shown to stimulate glucose incorporation in differentiated adipocytes, independent of insulin activity. It has been suggested that FGF21 also acts as key regulator in the adaptation to stress.

Sterile Filtered White lyophilized powder. Purified and tested for use in cell culture.

Source: Escherichia coli

MW: ~19.9 kDa (182 amino acids)

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by thymidine uptake assay using FGF-receptors transfected BaF3 cells is less than 0.5 μg/ml, corresponding to a specific activity of >2.0×103 IU/mg in the presence of 5 µg/ml of rMuKlotho-β and 10 μg/ml of heparin.

Purity: >97% by SDS-PAGE and HPLC analyses

Storage/Handling: Store desiccated at -20°C.

Mouse Genome Database ID:1861377

NOT FOR HUMAN USE!

Additional resources for this protein may be found at:
OMIM