Lymphoid/lymphocyte

Showing all 7 results

Product info

Catalog Id
Size
Price
1130-05-2
2 μg
117.00
1130-05-100
100 μg
608.00
1130-05-1000
1000 μg
2,772.00
1130-05-250
1,116.00
1130-05-500
1,668.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant human fms related tyrosine kinase 3 ligand
FLT3LG
FL; FLT3L

FLT3LG is a hematopoietic cytokine whose activities are mediated by binding to the transmembrane glycoprotein Flt3. Flt3 was first discovered as a member of the class III subfamily of receptor tyrosine kinases (RTK) whose expression among hematopoietic cells was found to be restricted to highly enriched stem/progenitor cell populations. Additionally, class III RTKs include the receptors from SCF, CSF3 and PDGF. Not surprisingly, FLT3LG is also structurally related to CSF3 and SCF. All three cytokines have been shown to exist both as type I transmembrane proteins and as soluble proteins. The predominant human FLT3LG isoform is a transmembrane protein that can undergo proteolytic cleavage to generate a soluble form of the protein. An alternatively-spliced FLT3LG mRNA, encoding a soluble form of the human FLT3LG, has also been identified. FLT3LG is widely expressed in various human and mouse tissues. At the amino acid sequence level, human and mouse FLT3LG are approximately 72% identical and the two proteins exhibit cross-species activity. FLT3LG has been shown to synergize with a wide variety of hematopoietic cytokines to stimulate the growth and differentiation of early hematopoietic progenitors.

Sterile Filtered White lyophilized powder.

Source: Escherichia coli

MW: ~17.6 kDa (155 amino acid)

Purity: >97% by SDS-PAGE and HPLC analyses

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human AML5 cells is less than 1.0 ng/ml, corresponding to a specific activity of >1.0 × 106 IU/mg.

Storage/Handling: Store desiccated at -20°C.

HGNC ID: 3766

NOT FOR HUMAN USE!

Additional resources for this protein may be found at:
OMIM

Product info

Catalog Id
Size
Price
1130-07-5
5 µg
117.00
1130-07-25
25 µg
172.00
1130-07-1000
1000 µg
2,092.00
1130-07-250
840.00
1130-07-500
1,316.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Human Leukemia Inhibitory Factor
LIF

Leukemia Inhibitory Factor (LIF) is a lymphoid factor which promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. LIF binds to the specific LIFR-α, which forms a heterodimer containing a GP130 signal transducing subunit.LIF is normally expressed in the trophectoderm of the developing embryo and has a number of other activities including cholinergic neuron differentiation, control of stem cell pluripotency, bone and fat metabolism, mitogenesis of certain factor dependent cell lines and promotion of megakaryocyte production in vivo. LIF is not required for human embryonic stem cell cultures.

Sterile Filtered White lyophilized powder

Source: Escherichia coli

MW: ~19.7 kDa (180 amino acid)

Purity: >98% by SDS-PAGE and HPLC analyses

Biological Activity: Fully biologically active when compared to standard. The specific activity determined by inducing differentiation of murine M1 myeloid leukemic cells. The minimum detectable concentration of rHuLIF in this assay is 0.5 ng/ml, corresponding to a specific activity of >2.0×106 IU/mg.

Store desiccated at -20°C.

HGNC: 6596

NOT FOR HUMAN USE!

Cross-species homology


Percent Similarity


Product info

Catalog Id
Size
Price
1330-07-5
5 µg
117.00
1330-07-25
25 µg
172.00
1330-07-1000
1000 µg
2,092.00
1330-07-250
840.00
1330-07-500
1,316.00
Description

GoldBio growth factors are manufactured for RESEARCH USE ONLY and cannot be sold for human consumption!

Recombinant Murine Leukemia Inhibitory Factor
LIF

Leukemia Inhibitory Factor (LIF) is a lymphoid factor which promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. LIF binds to the specific LIFR-α, which forms a heterodimer containing a GP130 signal transducing subunit.LIF is normally expressed in the trophectoderm of the developing embryo and has a number of other activities including cholinergic neuron differentiation, control of stem cell pluripotency, bone and fat metabolism, mitogenesis of certain factor dependent cell lines and promotion of megakaryocyte production in vivo. While LIF is not required for human embryonic stem cell cultures, it is commonly used for mouse embryonic stem cell cultures.

Sterile Filtered White lyophilized powder

Source: Escherichia coli

MW: ~19.9 kDa (180 amino acid)

Purity: >98% by SDS-PAGE and HPLC analyses

Biological Activity: Fully biologically active when compared to standard. The specific activity determined by inducing differentiation of murine M1 myeloid leukemic cells. The minimum detectable concentration of rMuLIF in this assay is 0.5 ng/ml, corresponding to a specific activity of >2.0×106 IU/mg.

Store desiccated at -20°C.

Mouse Genome Database: 96787

NOT FOR HUMAN USE!

Cross-species homology


Percent Similarity


Product info

Catalog Id
Size
Price
1130-01h-10
10 μg
156.00
1130-01h-50
50 μg
243.00
1130-01h-1000
1000 μg
2,922.00
Description

Product info

Catalog Id
Size
Price
1130-012-10
10 μg
156.00
1130-012-50
50 μg
243.00
1130-012-1000
1000 μg
3,294.00
Description

Product info

Catalog Id
Size
Price
1130-01-10
10 μg
156.00
1130-01-50
50 μg
243.00
1130-01-1000
1000 μg
2,922.00
Description

Product info

Catalog Id
Size
Price
1330-01-5
5 μg
219.00
1330-01-20
20 μg
339.00
1330-01-1000
1000 μg
5,104.00
Description