5-Fluorocytosine is a fluorinated cytosine analog and antifungal agent. 5-fluorocytosine becomes 5-fluorouracil and is then incorporated into RNA, causing miscoding and inhibition of DNA synthesis. It is effective against Candida and Cryptococcus species and can be used as a negative selection agent in transgenic plants.
5-Fluorocytosine is often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species. They are tested against gram-negative and gram-positive bacteria using panels, discs, and MIC strips by medical microbiologists. ASTs decrease the risk of using an antibiotic against bacteria exhibiting resistance to it, and the results are used in clinical settings to determine which antibiotic(s) to prescribe for various infections.
MOLECULAR BIOLOGY GRADE
MW: 129.09 g/mol
Storage/Handling: Store at 2-8°C. Protect from light.
PubChem Chemical ID: 3366