Albendazole is a benzimidazole derivative typically used as a comprehensive antiparasitic belonging to the anthelminthic group and works by disrupting microtubule formation. Microtubule disruption diminishes glucose transport which increases glycogen catabolism. Eventually, this net loss of energy results in tissue death.
The resulting tissue death caused by microtubule formation is a sought after mechanism in oncology research. In vitro research of albendazole on HNSCC (head and neck squamous cancer cells) had shown cell cycle arrest in G2/M stage, resulting in apoptosis. Disruption of microtubule formation also prevented malignant cell migration.
Methyl N-(6-propylsulfanyl-1H-benzimidazol-2-yl) carbamate
MW: 265.33 g/mol
Storage/Handling: Store at room temperature.
PubChem Chemical ID: 2082