Anisomycin is an antifungal produced by Streptomyces griseolus. It functions by inhibiting protein synthesis in certain eukaryotic cells. Anisomycin inhibits peptidyl transferase activity in the 60s subunit of the 80s ribosome.
Anisomycin has been shown to promote apoptosis in promyelocytic leukemia cells, Jurkat cells, ventricular monocytes, and colon adenocarcinoma cells. Additionally, anisomycin is a JNK agonist and activates MAP kinases. It is a useful antiprotozoal agent.
MOLECULAR BIOLOGY GRADE
MW: 265.30 g/mol
Storage/Handling: Store at 4°C.
PubChem Chemical ID: 253602
A-580-10, A-580-100, A-580-25, A-580-50, A-580-500