The cyclosporins are a group of macrolide immunosuppressants isolated from fungi. They are researched for their use in prevention of post-transplant graft rejection. Their mechanism of action involves suppression of cytotoxic T-cell maturation and activity by binding lymphocyte protein cyclophilin. Cyclophilin and cyclosporin form a complex targeting calcineurin, which is responsible for activating T-lymphocytes. Additionally, the cyclosporins are researched for their ability to prevent damage to normal functioning cells in autoimmune disorders.
Cyclosporin C is soluble in DMSO and ethyl alcohol.
MW: 1,218.61 g/mol
Storage/Handling: Store at -20°C.
Soluble in DMSO and EtOH
PubChem Chemical ID: 53395167
C-943-1, C-943-10, C-943-25, C-943-5, C-943-50