Erlotinib HCl is an anti-cancer agent targeting epidermal growth factor receptor (EGFR) tyrosine kinase ATP binding sites, which are commonly overexpressed and sometimes mutated in a variety of cancers. Erlotinib prevents the formation of EGFR homodimers leading to suppression of signal transmittance and tumor growth inhibition. Additionally, erlotinib suppresses cyclin-dependent kinase 2 (Cdk2). It has been shown to be effective against non-small cell lung cancer and pancreatic cancer.
MOLECULAR BIOLOGY GRADE
MW: 393.44 g/mol
Storage/Handling: Store at 2-8 °C. Product is soluble in acid (pH 2) at 0.4 mg/mL.
PubChem Chemical ID: 176870
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