Ingenol mebutate (Ingenol-3-mebutate) is a hydrophobic diterpene ester extracted from the plant Euphorbia peplus. This compound is used in oncology research as an activator of the protein kinase C (PKC) family. Ingenol mebutate has been effective against basal cell carcinomas, squamous cell carcinomas and actinic keratosis.
Research on stimulation of PKC pathways by ingenol mebutate were shown to promote apoptosis, arrest cell growth and increase neutrophilic infiltration. Halting cell growth subsequently leads to apoptosis due to intracellular signals triggered from a lack of progression in the cell cycle. Ingenol mebutate diminished relapse rates of mice tumors in vivo and in vitro by inducing neutrophil recruiting and activating pathways. These pathways include releasing inflammatory cytokines interleukin 8 (IL8), interleukin 1 (IL1) as well as tumor necrosis factor alpha (TNF-α) which attract neutrophils to the inflammatory site.
Ingenol mebutate (Ingenol-3-mebutate)
MW: 430.53 g/mol
Storage/Handling: Store desiccated at -20°C.
PubChem Chemical ID: 6918670
NOT FOR HUMAN CONSUMPTION!!