Ivermectin is a broad-spectrum antiparasitic drug of the avermectin family. Derived from Streptomyces avermitilis, ivermectin is a positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors. It also regulates glutamate-GABA-activated chloride channels.
The mechanism of ivermectin is not well understood. It is thought to target nematode neurotransmitters causing paralysis and death. Ivermectin also inhibits secretions of parasitic proteins necessary for parasites to evade the host immune system.
Ivermectin is insoluble.
Ivermectin, USP Grade
MW: 875.09 g/mol
Storage/Handling: Store at 4°C.
PubChem Chemical ID: 71308642
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