Description
Ketoconazole is a broad-spectrum imidazole antifungal effective against a variety of fungal species including Candida species, Blastomyces species, and Histoplasma
species. Ketoconazole functions by inhibiting ergosterol synthesis and
increasing fungal cell membrane permeability. It is also a CYP3A4
inhibitor used to identify p-glycoprotein/CYP3A-limited bioavailability
and to study interleukin 1 chemotherapeutic effects. It has also been
used to study drug interactions and to inhibit synthesis of aldosterone,
cortisol, and testosterone.
Ketoconazole is often used in clinical in vitro tests known as
antimicrobial susceptibility tests or ASTs to determine their efficacy
against certain bacterial species. They are tested against gram-negative
and gram-positive bacteria using panels, discs, and MIC strips by
medical microbiologists. ASTs decrease the risk of using an antibiotic
against bacteria exhibiting resistance to it, and the results are used
in clinical settings to determine which antibiotic(s) to prescribe for
various infections.
Product Specifications
Ketoconazole
Formula: C26H28Cl2N4O4
MW: 531.43 g/mol
Storage/Handling: Store at 4°C.
This product is soluble in methanol and methylene chloride.
PubChem Chemical ID: 456201
