Description
| Description | Oxolinic acid is a synthetic antimicrobial related to NALIDIXIC ACID and used in URINARY TRACT INFECTIONS. |
| Targets&IC50 | dopamine uptake:4.3 μM |
| In vitro | Oxolinic acid, a quinolone antibacterial agent, inhibits reversibly the ATP-dependent replicative DNA synthesis in permeable cell systems as well as in cellophane disk lysates[4]. It also inhibits bacterial DNA gyrase but not eukaryotic topoisomerases, reversibly binding gyrase subunit A in gyrase-DNA complexes, blocking supercoiling activity and inhibiting DNA synthesis at 0.5-5 μg/ml[5][6][7]. |
| In vivo | The antimicrobial agent oxolinic acid, injected i.p. in mice, induces a dose dependent increase in locomotor activity. the stimulant locomotor effect of oxolinic acid depends on the blockade of the neuronal dopamine uptake complex[2]. |
| Synonyms | Dioxacin, Urinox, Emyrenil, Nidantin, NSC 110364 |
| Molecular Weight |
261.24 |
| Formula | C13H11NO5 |
| CAS No. | 14698-29-4 |
Storage
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Solubility Information
DMSO: 2.5 mM
( < 1 mg/ml refers to the product slightly soluble or insoluble )
