Thiostrepton is a cyclic peptide antibiotic isolated from Streptomyces azureus. It targets a wide variety of gram-negative and gram-positive bacteria, especially those causing skin infections. It has been used as a marker for selection of recombinant Streptomyces cultures. Additionally, thiostrepton has been shown to inhibit FOXM1, a gene commonly overexpressed in cancer cell lines, thus inhibiting cancer cell growth.
Thiostrepton functions by binding elongation factor G (EF-G) and interfering with ribosomal GTPase activity, ultimately inhibiting protein synthesis.
MOLECULAR BIOLOGY GRADE
MW: 1,664.89 g/mol
Storage/Handling: Store at -20°C.
This product is soluble in acetic acid, chloroform, DMF, and DMSO.
PubChem Chemical ID: 16129666